Association of Prediabetes and Type 2 Diabetes With Cognitive Function After Stroke: A STROKOG Collaboration Study

Jessica W. Lo*, John D. Crawford, Katherine Samaras, David W. Desmond, Sebastian Kohler, Julie Staals, Frans R. J. Verhey, Hee-Joon Bae, Keon-Joo Lee, Beom Joon Kim, Regis Bordet, Charlotte Cordonnier, Thibaut Dondaine, Anne-Marie Mendyk, Byung-Chul Lee, Kyung-Ho Yu, Jae-Sung Lim, Nagaendran Kandiah, Russell J. Chander, Chathuri YatawaraDarren M. Lipnicki, Perminder S. Sachdev, STROKOG Collaboration

*Corresponding author for this work

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Abstract

Background and Purpose-

Type 2 diabetes mellitus (T2D) is associated with cognitive impairment and an increased risk of dementia, but the association between prediabetes and cognitive impairment is less clear, particularly in a setting of major cerebrovascular events. This article examines the impact of impaired fasting glucose and T2D on cognitive performance in a stroke population.

Methods-

Seven international observational studies from the STROKOG (Stroke and Cognition) consortium (n=1601; mean age, 66.0 years; 70% Asian, 26% white, and 2.6% African American) were included. Fasting glucose level (FGL) during hospitalization was used to define 3 groups, T2D (FGL >= 7.0 mmol/L), impaired fasting glucose (FGL 6.1-6.9 mmol/L), and normal (FGL

Results-

Patients with T2D had significantly poorer performance in global cognition (SD, -0.59 [95% CI, -0.82 to -0.36]; P

Conclusions-

Diabetes mellitus, but not prediabetes, is associated with poorer cognitive performance in patients 3 to 6 months after stroke.

Original languageEnglish
Pages (from-to)1640-1646
Number of pages7
JournalStroke
Volume51
Issue number6
DOIs
Publication statusPublished - Jun 2020

Keywords

  • cognition
  • diabetes mellitus
  • prediabetic state
  • stroke
  • IMPAIRED FASTING GLUCOSE
  • BLOOD-GLUCOSE
  • RISK-FACTORS
  • DECLINE
  • COMMUNITY
  • DEMENTIA
  • MELLITUS

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