TY - JOUR
T1 - Association of pre-transplant dialysis duration with outcome in kidney transplant recipients: a prevalent cohort study
AU - Remport, Adam
AU - Keszei, Andras
AU - Vamos, Eszter Panna
AU - Novak, Marta
AU - Jaray, Jeno
AU - Rosivall, Laszlo
AU - Mucsi, Istvan
AU - Molnar, Miklos Zsolt
PY - 2011/3
Y1 - 2011/3
N2 - Dialysis treatment prior to transplantation may contribute to premature mortality and graft loss in kidney-transplanted patients. In this prevalent cohort study (TransQol-HU Study), we analyzed the association between pre-transplant dialysis duration versus mortality and death-censored graft loss in kidney-transplanted patients. Data from 926 kidney-transplanted patients followed at a single outpatient transplant center were analyzed. Socio-demographic parameters, laboratory data, medical history, donor characteristics and information on co-morbidities were collected at baseline. Data on 5-year outcome (graft loss, mortality) were collected. In multivariate analyses, pre-transplant dialysis duration was an independent risk factor for mortality (HRfor each month increase = 1.011; 95% CI: 1.005-1.016) and also for death-censored graft loss (HRfor each month increase = 1.008; 95% CI: 1.001-1.015) after adjustment for several co-variables. In the multivariate model, patients with less than 1 year (HR = 0.498; 95% CI: 0.302-0.820; P = 0.006) and 1-3 years (HR = 0.577; 95% CI: 0.371-0.899; P = 0.015) of pre-transplant dialysis had significantly better survival after transplantation compared to those with more than 3 years on dialysis. These findings add further strength to existing evidence about the significant association between longer pre-transplant dialysis duration and poor outcome in kidney-transplanted patients.
AB - Dialysis treatment prior to transplantation may contribute to premature mortality and graft loss in kidney-transplanted patients. In this prevalent cohort study (TransQol-HU Study), we analyzed the association between pre-transplant dialysis duration versus mortality and death-censored graft loss in kidney-transplanted patients. Data from 926 kidney-transplanted patients followed at a single outpatient transplant center were analyzed. Socio-demographic parameters, laboratory data, medical history, donor characteristics and information on co-morbidities were collected at baseline. Data on 5-year outcome (graft loss, mortality) were collected. In multivariate analyses, pre-transplant dialysis duration was an independent risk factor for mortality (HRfor each month increase = 1.011; 95% CI: 1.005-1.016) and also for death-censored graft loss (HRfor each month increase = 1.008; 95% CI: 1.001-1.015) after adjustment for several co-variables. In the multivariate model, patients with less than 1 year (HR = 0.498; 95% CI: 0.302-0.820; P = 0.006) and 1-3 years (HR = 0.577; 95% CI: 0.371-0.899; P = 0.015) of pre-transplant dialysis had significantly better survival after transplantation compared to those with more than 3 years on dialysis. These findings add further strength to existing evidence about the significant association between longer pre-transplant dialysis duration and poor outcome in kidney-transplanted patients.
KW - Chronic renal disease
KW - Dialysis duration
KW - Kidney transplantation
KW - Mortality
KW - Transplantation outcomes
U2 - 10.1007/s11255-009-9700-4
DO - 10.1007/s11255-009-9700-4
M3 - Article
C2 - 20058186
SN - 0301-1623
VL - 43
SP - 215
EP - 224
JO - International Urology and Nephrology
JF - International Urology and Nephrology
IS - 1
ER -