TY - JOUR
T1 - Association of physical activity and sedentary time with structural brain networks-The Maastricht Study
AU - Vergoossen, Laura W. M.
AU - Jansen, J. F. A.
AU - de Jong, J. J. A.
AU - Stehouwer, C. D. A.
AU - Schaper, N. C.
AU - Savelberg, H. H. C. M.
AU - Koster, A.
AU - Backes, W. H.
AU - Schram, M. T.
N1 - Funding Information:
This study was supported by the European Regional Development Fund via OP-Zuid, the Province of Limburg, the Dutch Ministry of Economic Affairs (grant 31O.041), Stichting De Weijerhorst (Maastricht, the Netherlands), the Pearl String Initiative Diabetes (Amsterdam, the Netherlands), CARIM, School for Cardiovascular Diseases (Maastricht, the Netherlands), School CAPHRI, Care and Public Health Research Institute (Maastricht, the Netherlands), NUTRIM, School of Nutrition and Translational Research in Metabolism (Maastricht, the Netherlands), Stichting Annadal (Maastricht, the Netherlands), Health Foundation Limburg (Maastricht, the Netherlands), and unrestricted grants from Janssen-Cilag B.V. (Tilburg, the Netherlands), Novo Nordisk Farma B.V. (Alphen aan den Rijn, the Netherlands), and Sanofi-Aventis Netherlands B.V. (Gouda, the Netherlands).
Publisher Copyright:
© 2020, The Author(s).
PY - 2021/2
Y1 - 2021/2
N2 - We assessed whether objectively measured low- and high-intensity physical activity (LPA and HPA) and sedentary time (ST) were associated with white matter connectivity, both throughout the whole brain and in brain regions involved in motor function. In the large population-based Maastricht Study (n= 1715, age 59.6 +/- 8.1 (mean +/- standard deviation) years, and 48% women), the amounts of LPA, HPA, and ST were objectively measured during 7 days by an activPAL accelerometer. In addition, using 3T structural and diffusion MRI, we calculated whole brain node degree and node degree of the basal ganglia and primary motor cortex. Multivariable linear regression analysis was performed, and we report standardized regression coefficients (st beta) adjusted for age, sex, education level, wake time, diabetes status, BMI, office systolic blood pressure, antihypertensive medication, total-cholesterol-to-HDL-cholesterol ratio, lipid-modifying medication, alcohol use, smoking status, and history of cardiovascular disease. Lower HPA was associated with lower whole brain node degree after full adjustment (st beta [95%CI] = - 0.062 [- 0.101, - 0.013];p= 0.014), whereas lower LPA (st beta [95%CI] = - 0.013 [- 0.061, 0.034];p= 0.580) and higher ST (st beta [95%CI] = - 0.030 [- 0.081, 0.021];p= 0.250) was not. In addition, lower HPA was associated with lower node degree of the basal ganglia after full adjustment (st beta [95%CI] = - 0.070 [- 0.121, - 0.018];p= 0.009). Objectively measured lower HPA, but not lower LPA and higher ST, was associated with lower whole brain node degree and node degree in specific brain regions highly specialized in motor function. Further research is needed to establish whether more HPA may preserve structural brain connectivity.
AB - We assessed whether objectively measured low- and high-intensity physical activity (LPA and HPA) and sedentary time (ST) were associated with white matter connectivity, both throughout the whole brain and in brain regions involved in motor function. In the large population-based Maastricht Study (n= 1715, age 59.6 +/- 8.1 (mean +/- standard deviation) years, and 48% women), the amounts of LPA, HPA, and ST were objectively measured during 7 days by an activPAL accelerometer. In addition, using 3T structural and diffusion MRI, we calculated whole brain node degree and node degree of the basal ganglia and primary motor cortex. Multivariable linear regression analysis was performed, and we report standardized regression coefficients (st beta) adjusted for age, sex, education level, wake time, diabetes status, BMI, office systolic blood pressure, antihypertensive medication, total-cholesterol-to-HDL-cholesterol ratio, lipid-modifying medication, alcohol use, smoking status, and history of cardiovascular disease. Lower HPA was associated with lower whole brain node degree after full adjustment (st beta [95%CI] = - 0.062 [- 0.101, - 0.013];p= 0.014), whereas lower LPA (st beta [95%CI] = - 0.013 [- 0.061, 0.034];p= 0.580) and higher ST (st beta [95%CI] = - 0.030 [- 0.081, 0.021];p= 0.250) was not. In addition, lower HPA was associated with lower node degree of the basal ganglia after full adjustment (st beta [95%CI] = - 0.070 [- 0.121, - 0.018];p= 0.009). Objectively measured lower HPA, but not lower LPA and higher ST, was associated with lower whole brain node degree and node degree in specific brain regions highly specialized in motor function. Further research is needed to establish whether more HPA may preserve structural brain connectivity.
KW - Physical activity
KW - Sedentary behavior
KW - Structural connectivity
KW - Elderly population-based cohort
KW - OLDER-ADULTS
KW - TISSUE SEGMENTATION
KW - MOTOR CONTROL
KW - ABNORMALITIES
KW - EXERCISE
KW - AGE
U2 - 10.1007/s11357-020-00276-z
DO - 10.1007/s11357-020-00276-z
M3 - Article
C2 - 33034792
SN - 2509-2715
VL - 43
SP - 239
EP - 252
JO - Geroscience
JF - Geroscience
IS - 1
ER -