Association of Hearing Impairment with Incident Depressive Symptoms: A Community-Based Prospective Study

Quentin Lisan; Thomas T. van Sloten; Cedric Lemogne; Lucille Offredo; Rachel E. Climie; Pierre Boutouyrie; Catherine Guibout; Frederique Thomas; Nicolas Danchin; Xavier Jouven; Jen-Philippe Empana

doi:10.1016/j.amjmed.2019.05.039

Association of Hearing Impairment with Incident Depressive Symptoms: A Community-Based Prospective Study

Quentin Lisan^*, Thomas T. van Sloten, Cedric Lemogne, Lucille Offredo, Rachel E. Climie, Pierre Boutouyrie, Catherine Guibout, Frederique Thomas, Nicolas Danchin, Xavier Jouven, Jen-Philippe Empana

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

OBJECTIVE: The aim was to investigate the potential association between hearing impairment and incident depressive symptoms.

METHODS: Using a prospective community-based cohort study in France (the Paris Prospective Study III), participants aged 50-75 years were recruited between 2008 and 2012 and thereafter followed up every 2 years up to 2018. Hearing impairment, measured at study recruitment by audiometry testing, was defined as a pure tone average >25 decibels in the better ear. Incident depressive symptoms, measured using the validated 13-item Questionnaire of Depression 2nd version, was assessed during follow-up. Multivariate generalized estimating equations were used to compute odds ratio (OR) and 95% confidence intervals (CI).

RESULTS: Among 7591 participants free of depressive symptoms at baseline (mean age 59.8 years, 63% of men), 14.3% had hearing impairment. Over 6 years of follow-up, 479 subjects (6.3%) had incident depressive symptoms. The OR for incident depressive symptoms was 1.36 for subjects with baseline hearing impairment (95% CI, 1.06-1.73). A pooled analysis of 4 published prospective studies yielded a multivariable relative risk of baseline hearing impairment for incident depressive symptoms of 1.29 (95% CI, 1.09-1.53).

CONCLUSIONS: In this community-based prospective cohort study of participants aged 50 to 75 years, baseline hearing impairment was associated with a 36% increased odds of incident depressive symptoms. (C) 2019 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	1441-1449.e4
Number of pages	13
Journal	American Journal of Medicine
Volume	132
Issue number	12
DOIs	https://doi.org/10.1016/j.amjmed.2019.05.039
Publication status	Published - Dec 2019

Keywords

Cohort study
Depressive symptoms
Hearing impairment
Prospective
SELF-REPORTED HEARING
LATE-LIFE DEPRESSION
OLDER-ADULTS
POPULATION
PREVALENCE
REGRESSION
MORTALITY
ANXIETY
RISK

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Cite this

@article{fa1402a0d3a5434eb9bb7c7a4cdd3ba8,

title = "Association of Hearing Impairment with Incident Depressive Symptoms: A Community-Based Prospective Study",

abstract = "OBJECTIVE: The aim was to investigate the potential association between hearing impairment and incident depressive symptoms.METHODS: Using a prospective community-based cohort study in France (the Paris Prospective Study III), participants aged 50-75 years were recruited between 2008 and 2012 and thereafter followed up every 2 years up to 2018. Hearing impairment, measured at study recruitment by audiometry testing, was defined as a pure tone average >25 decibels in the better ear. Incident depressive symptoms, measured using the validated 13-item Questionnaire of Depression 2nd version, was assessed during follow-up. Multivariate generalized estimating equations were used to compute odds ratio (OR) and 95% confidence intervals (CI).RESULTS: Among 7591 participants free of depressive symptoms at baseline (mean age 59.8 years, 63% of men), 14.3% had hearing impairment. Over 6 years of follow-up, 479 subjects (6.3%) had incident depressive symptoms. The OR for incident depressive symptoms was 1.36 for subjects with baseline hearing impairment (95% CI, 1.06-1.73). A pooled analysis of 4 published prospective studies yielded a multivariable relative risk of baseline hearing impairment for incident depressive symptoms of 1.29 (95% CI, 1.09-1.53).CONCLUSIONS: In this community-based prospective cohort study of participants aged 50 to 75 years, baseline hearing impairment was associated with a 36% increased odds of incident depressive symptoms. (C) 2019 Elsevier Inc. All rights reserved.",

keywords = "Cohort study, Depressive symptoms, Hearing impairment, Prospective, SELF-REPORTED HEARING, LATE-LIFE DEPRESSION, OLDER-ADULTS, POPULATION, PREVALENCE, REGRESSION, MORTALITY, ANXIETY, RISK",

author = "Quentin Lisan and {van Sloten}, {Thomas T.} and Cedric Lemogne and Lucille Offredo and Climie, {Rachel E.} and Pierre Boutouyrie and Catherine Guibout and Frederique Thomas and Nicolas Danchin and Xavier Jouven and Jen-Philippe Empana",

note = "Funding Information: We thank N. Estrugo, S. Yanes, J.F. Pruny and J. Lacet Machado for performing the study recruitment of PPS3 study participants, Dr. M.F. Eprinchard, Dr. J.M. Kirzin, and all the medical and technical staff of the IPC Center, the Centre de Ressources Biologiques of the European Hospital Georges Pompidou staff (C. de Toma, B. Vedie), and the Platform for Biological Resources of the European Hospital Georges Pompidou for the management of the biobank. The PPS3 is organized under an agreement between Institut National de la Sant{\'e} et de la Recherche M{\'e}dicale (INSERM) and the IPC Center, and between INSERM and the Ressources Biologiques of European Hospital Georges Pompidou, Paris, France. We also thank the Caisse Nationale d'Assurance Maladie des Travailleurs Salari{\'e}s (CNAM-TS, France) and the Caisse Primaire d'Assurance Maladie de Paris (CPAM-P, France) for helping make this study possible. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = dec,

doi = "10.1016/j.amjmed.2019.05.039",

language = "English",

volume = "132",

pages = "1441--1449.e4",

journal = "American Journal of Medicine",

issn = "0002-9343",

publisher = "Elsevier Science",

number = "12",

}

TY - JOUR

T1 - Association of Hearing Impairment with Incident Depressive Symptoms

T2 - A Community-Based Prospective Study

AU - Lisan, Quentin

AU - van Sloten, Thomas T.

AU - Lemogne, Cedric

AU - Offredo, Lucille

AU - Climie, Rachel E.

AU - Boutouyrie, Pierre

AU - Guibout, Catherine

AU - Thomas, Frederique

AU - Danchin, Nicolas

AU - Jouven, Xavier

AU - Empana, Jen-Philippe

N1 - Funding Information: We thank N. Estrugo, S. Yanes, J.F. Pruny and J. Lacet Machado for performing the study recruitment of PPS3 study participants, Dr. M.F. Eprinchard, Dr. J.M. Kirzin, and all the medical and technical staff of the IPC Center, the Centre de Ressources Biologiques of the European Hospital Georges Pompidou staff (C. de Toma, B. Vedie), and the Platform for Biological Resources of the European Hospital Georges Pompidou for the management of the biobank. The PPS3 is organized under an agreement between Institut National de la Santé et de la Recherche Médicale (INSERM) and the IPC Center, and between INSERM and the Ressources Biologiques of European Hospital Georges Pompidou, Paris, France. We also thank the Caisse Nationale d'Assurance Maladie des Travailleurs Salariés (CNAM-TS, France) and the Caisse Primaire d'Assurance Maladie de Paris (CPAM-P, France) for helping make this study possible. Publisher Copyright: © 2019 Elsevier Inc.

PY - 2019/12

Y1 - 2019/12

N2 - OBJECTIVE: The aim was to investigate the potential association between hearing impairment and incident depressive symptoms.METHODS: Using a prospective community-based cohort study in France (the Paris Prospective Study III), participants aged 50-75 years were recruited between 2008 and 2012 and thereafter followed up every 2 years up to 2018. Hearing impairment, measured at study recruitment by audiometry testing, was defined as a pure tone average >25 decibels in the better ear. Incident depressive symptoms, measured using the validated 13-item Questionnaire of Depression 2nd version, was assessed during follow-up. Multivariate generalized estimating equations were used to compute odds ratio (OR) and 95% confidence intervals (CI).RESULTS: Among 7591 participants free of depressive symptoms at baseline (mean age 59.8 years, 63% of men), 14.3% had hearing impairment. Over 6 years of follow-up, 479 subjects (6.3%) had incident depressive symptoms. The OR for incident depressive symptoms was 1.36 for subjects with baseline hearing impairment (95% CI, 1.06-1.73). A pooled analysis of 4 published prospective studies yielded a multivariable relative risk of baseline hearing impairment for incident depressive symptoms of 1.29 (95% CI, 1.09-1.53).CONCLUSIONS: In this community-based prospective cohort study of participants aged 50 to 75 years, baseline hearing impairment was associated with a 36% increased odds of incident depressive symptoms. (C) 2019 Elsevier Inc. All rights reserved.

AB - OBJECTIVE: The aim was to investigate the potential association between hearing impairment and incident depressive symptoms.METHODS: Using a prospective community-based cohort study in France (the Paris Prospective Study III), participants aged 50-75 years were recruited between 2008 and 2012 and thereafter followed up every 2 years up to 2018. Hearing impairment, measured at study recruitment by audiometry testing, was defined as a pure tone average >25 decibels in the better ear. Incident depressive symptoms, measured using the validated 13-item Questionnaire of Depression 2nd version, was assessed during follow-up. Multivariate generalized estimating equations were used to compute odds ratio (OR) and 95% confidence intervals (CI).RESULTS: Among 7591 participants free of depressive symptoms at baseline (mean age 59.8 years, 63% of men), 14.3% had hearing impairment. Over 6 years of follow-up, 479 subjects (6.3%) had incident depressive symptoms. The OR for incident depressive symptoms was 1.36 for subjects with baseline hearing impairment (95% CI, 1.06-1.73). A pooled analysis of 4 published prospective studies yielded a multivariable relative risk of baseline hearing impairment for incident depressive symptoms of 1.29 (95% CI, 1.09-1.53).CONCLUSIONS: In this community-based prospective cohort study of participants aged 50 to 75 years, baseline hearing impairment was associated with a 36% increased odds of incident depressive symptoms. (C) 2019 Elsevier Inc. All rights reserved.

KW - Cohort study

KW - Depressive symptoms

KW - Hearing impairment

KW - Prospective

KW - SELF-REPORTED HEARING

KW - LATE-LIFE DEPRESSION

KW - OLDER-ADULTS

KW - POPULATION

KW - PREVALENCE

KW - REGRESSION

KW - MORTALITY

KW - ANXIETY

KW - RISK

U2 - 10.1016/j.amjmed.2019.05.039

DO - 10.1016/j.amjmed.2019.05.039

M3 - Article

C2 - 31247178

SN - 0002-9343

VL - 132

SP - 1441-1449.e4

JO - American Journal of Medicine

JF - American Journal of Medicine

IS - 12

ER -