Association of echocardiographic left ventricular structure with the ACE D/I polymorphism: a meta-analysis

Yu Jin, Tatiana Kuznetsova, Lutgarde Thijs, Tom Richart, Katarzyna Stolarz-Skrzypek, Yanping Liu, Robert Fagard, Paolo Manunta, Giuseppe Bianchi, Jan A. Staessen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Web of Science)


Introduction: In a previous meta-analysis, we derived pooled estimates for the association of left ventricular mass (LVM) and hypertrophy (LVH), as diagnosed by electrocardiography or echocardiography, with the ACE D/I polymorphism. We updated this meta-analysis until May 2009 only considering echocardiographic phenotypes. Methods: We computed pooled estimates from a random-effects model. Results: Across 38 studies, both DD homozygotes (n = 2440) and DI heterozygotes (n = 4310) had higher (p
Original languageEnglish
Pages (from-to)243-253
JournalJournal of the Renin-angiotensin-aldosterone System
Issue number3
Publication statusPublished - Sep 2011


  • ACE
  • echocardiography
  • left ventricular geometry
  • left ventricular mass
  • meta-analysis

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