Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer: a pooled analysis of individual patient data from three randomized trials

Willem J A Witlox*, Bram L T Ramaekers, Benjamin Lacas, Cecile Le Pechoux, Alexander Sun, Si-Yu Wang, Chen Hu, Mary Redman, Vincent van der Noort, Ning Li, Matthias Guckenberger, Harm van Tinteren, Harry J M Groen, Manuela A Joore, Dirk K M De Ruysscher

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


We assessed the impact of different PCI fractionation schedules (30 Gy in 10 versus 15 fractions) on brain metastases-free survival (BMFS) and toxicity in stage III NSCLC. Our results suggest that 30 Gy in 10 fractions is associated with increased toxicity, while no conclusive evidence of improving BMFS was seen with this schedule. (c) 2021 The Author(s). Published by Elsevier B.V. Radiotherapy and Oncology 164 (2021) 163-166 This is an open access article under the CC BY license (

Original languageEnglish
Pages (from-to)163-166
Number of pages4
JournalRadiotherapy and Oncology
Early online date4 Oct 2021
Publication statusPublished - Nov 2021


  • Brain metastases-free survival
  • Non-small cell lung cancer
  • Prophylactic cranial irradiation
  • RTOG 0212
  • Toxicity

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