Association of connective tissue growth factor with fibrosis in vitreoretinal disorders in the human eye

Esther J Kuiper; Marc D de Smet; Jan C van Meurs; H Stevie Tan; Michael W T Tanck; Noelynn Oliver; Frans A van Nieuwenhoven; Roel Goldschmeding; Reinier O Schlingemann

doi:10.1001/archopht.124.10.1457

Association of connective tissue growth factor with fibrosis in vitreoretinal disorders in the human eye

Esther J Kuiper
, Marc D de Smet
, Jan C van Meurs
, H Stevie Tan
, Michael W T Tanck
, Noelynn Oliver
, Frans A van Nieuwenhoven
, Roel Goldschmeding
, Reinier O Schlingemann^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: To investigate the expression of the profibrotic connective tissue growth factor (CTGF) in relation to severity of intraocular fibrosis and neovascularization in human vitreoretinal disorders for the identification of potential therapeutic targets to prevent fibrosis.

METHODS: Concentrations of CTGF were measured by enzyme-linked immunosorbent assay in 119 vitreous samples from patients with proliferative diabetic retinopathy, proliferative vitreoretinopathy, epiretinal membrane, and macular hole. Clinical data, including degree of intraocular fibrosis and neovascularization, were collected using standardized forms.

RESULTS: Multifactorial analysis revealed that only CTGF levels correlated highly significantly with degree of fibrosis in the various vitreoretinal disorders studied (P<.001; R2= 47.7%). Likewise, variation in degree of fibrosis was best predicted by CTGF levels (P<.001).

CONCLUSION: The strong correlation between CTGF levels and degree of fibrosis in vitreoretinal disorders suggests that CTGF is an important factor in ocular fibrosis, similar to its role in pathologic fibrosis in other organs.

CLINICAL RELEVANCE: Connective tissue growth factor may be a therapeutic target for prevention of sight-threatening vitreoretinal scarring in the eye.

Original language	English
Pages (from-to)	1457-62
Number of pages	6
Journal	Archives of Ophthalmology
Volume	124
Issue number	10
DOIs	https://doi.org/10.1001/archopht.124.10.1457
Publication status	Published - Oct 2006
Externally published	Yes

Keywords

Connective Tissue Growth Factor
Diabetic Retinopathy/metabolism
Enzyme-Linked Immunosorbent Assay
Epiretinal Membrane/metabolism
Female
Fibrosis/metabolism
Humans
Immediate-Early Proteins/metabolism
Intercellular Signaling Peptides and Proteins/metabolism
Male
Middle Aged
Retina/pathology
Retinal Perforations/metabolism
Vitreoretinopathy, Proliferative/metabolism
Vitreous Body/metabolism

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10.1001/archopht.124.10.1457

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title = "Association of connective tissue growth factor with fibrosis in vitreoretinal disorders in the human eye",

abstract = "OBJECTIVE: To investigate the expression of the profibrotic connective tissue growth factor (CTGF) in relation to severity of intraocular fibrosis and neovascularization in human vitreoretinal disorders for the identification of potential therapeutic targets to prevent fibrosis.METHODS: Concentrations of CTGF were measured by enzyme-linked immunosorbent assay in 119 vitreous samples from patients with proliferative diabetic retinopathy, proliferative vitreoretinopathy, epiretinal membrane, and macular hole. Clinical data, including degree of intraocular fibrosis and neovascularization, were collected using standardized forms.RESULTS: Multifactorial analysis revealed that only CTGF levels correlated highly significantly with degree of fibrosis in the various vitreoretinal disorders studied (P<.001; R2= 47.7\%). Likewise, variation in degree of fibrosis was best predicted by CTGF levels (P<.001).CONCLUSION: The strong correlation between CTGF levels and degree of fibrosis in vitreoretinal disorders suggests that CTGF is an important factor in ocular fibrosis, similar to its role in pathologic fibrosis in other organs.CLINICAL RELEVANCE: Connective tissue growth factor may be a therapeutic target for prevention of sight-threatening vitreoretinal scarring in the eye.",

keywords = "Connective Tissue Growth Factor, Diabetic Retinopathy/metabolism, Enzyme-Linked Immunosorbent Assay, Epiretinal Membrane/metabolism, Female, Fibrosis/metabolism, Humans, Immediate-Early Proteins/metabolism, Intercellular Signaling Peptides and Proteins/metabolism, Male, Middle Aged, Retina/pathology, Retinal Perforations/metabolism, Vitreoretinopathy, Proliferative/metabolism, Vitreous Body/metabolism",

author = "Kuiper, \{Esther J\} and \{de Smet\}, \{Marc D\} and \{van Meurs\}, \{Jan C\} and Tan, \{H Stevie\} and Tanck, \{Michael W T\} and Noelynn Oliver and \{van Nieuwenhoven\}, \{Frans A\} and Roel Goldschmeding and Schlingemann, \{Reinier O\}",

year = "2006",

month = oct,

doi = "10.1001/archopht.124.10.1457",

language = "English",

volume = "124",

pages = "1457--62",

journal = "Archives of Ophthalmology",

issn = "0003-9950",

publisher = "AMA",

number = "10",

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T1 - Association of connective tissue growth factor with fibrosis in vitreoretinal disorders in the human eye

AU - Kuiper, Esther J

AU - de Smet, Marc D

AU - van Meurs, Jan C

AU - Tan, H Stevie

AU - Tanck, Michael W T

AU - Oliver, Noelynn

AU - van Nieuwenhoven, Frans A

AU - Goldschmeding, Roel

AU - Schlingemann, Reinier O

PY - 2006/10

Y1 - 2006/10

N2 - OBJECTIVE: To investigate the expression of the profibrotic connective tissue growth factor (CTGF) in relation to severity of intraocular fibrosis and neovascularization in human vitreoretinal disorders for the identification of potential therapeutic targets to prevent fibrosis.METHODS: Concentrations of CTGF were measured by enzyme-linked immunosorbent assay in 119 vitreous samples from patients with proliferative diabetic retinopathy, proliferative vitreoretinopathy, epiretinal membrane, and macular hole. Clinical data, including degree of intraocular fibrosis and neovascularization, were collected using standardized forms.RESULTS: Multifactorial analysis revealed that only CTGF levels correlated highly significantly with degree of fibrosis in the various vitreoretinal disorders studied (P<.001; R2= 47.7%). Likewise, variation in degree of fibrosis was best predicted by CTGF levels (P<.001).CONCLUSION: The strong correlation between CTGF levels and degree of fibrosis in vitreoretinal disorders suggests that CTGF is an important factor in ocular fibrosis, similar to its role in pathologic fibrosis in other organs.CLINICAL RELEVANCE: Connective tissue growth factor may be a therapeutic target for prevention of sight-threatening vitreoretinal scarring in the eye.

AB - OBJECTIVE: To investigate the expression of the profibrotic connective tissue growth factor (CTGF) in relation to severity of intraocular fibrosis and neovascularization in human vitreoretinal disorders for the identification of potential therapeutic targets to prevent fibrosis.METHODS: Concentrations of CTGF were measured by enzyme-linked immunosorbent assay in 119 vitreous samples from patients with proliferative diabetic retinopathy, proliferative vitreoretinopathy, epiretinal membrane, and macular hole. Clinical data, including degree of intraocular fibrosis and neovascularization, were collected using standardized forms.RESULTS: Multifactorial analysis revealed that only CTGF levels correlated highly significantly with degree of fibrosis in the various vitreoretinal disorders studied (P<.001; R2= 47.7%). Likewise, variation in degree of fibrosis was best predicted by CTGF levels (P<.001).CONCLUSION: The strong correlation between CTGF levels and degree of fibrosis in vitreoretinal disorders suggests that CTGF is an important factor in ocular fibrosis, similar to its role in pathologic fibrosis in other organs.CLINICAL RELEVANCE: Connective tissue growth factor may be a therapeutic target for prevention of sight-threatening vitreoretinal scarring in the eye.

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KW - Diabetic Retinopathy/metabolism

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KW - Epiretinal Membrane/metabolism

KW - Female

KW - Fibrosis/metabolism

KW - Humans

KW - Immediate-Early Proteins/metabolism

KW - Intercellular Signaling Peptides and Proteins/metabolism

KW - Male

KW - Middle Aged

KW - Retina/pathology

KW - Retinal Perforations/metabolism

KW - Vitreoretinopathy, Proliferative/metabolism

KW - Vitreous Body/metabolism

U2 - 10.1001/archopht.124.10.1457

DO - 10.1001/archopht.124.10.1457

M3 - Article

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SN - 0003-9950

VL - 124

SP - 1457

EP - 1462

JO - Archives of Ophthalmology

JF - Archives of Ophthalmology

IS - 10

ER -

Association of connective tissue growth factor with fibrosis in vitreoretinal disorders in the human eye

Abstract

Keywords

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