Association of change in brain structure to objectively measured physical activity and sedentary behavior in older adults: Age, Gene/Environment Susceptibility-Reykjavik Study

N.Y. Arnardottir*, A. Koster, D.R. van Domelen, R.J. Brychta, P. Caserotti, G. Eiriksdottir, J.E. Sverrisdottir, S. Sigurdsson, E. Johannsson, K.Y. Chen, V. Gudnason, T.B. Harris, L.J. Launer, T. Sveinsson

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Many studies have examined the hypothesis that greater participation in physical activity (PA) is associated with less brain atrophy. Here we examine, in a sub-sample (n = 352, mean age 79.1 years) of the Age, Gene/Environment Susceptibility-Reykjavik Study cohort, the association of the baseline and 5-year change in magnetic resonance imaging (MRI)-derived volumes of gray matter (GM) and white matter (WM) to active and sedentary behavior (SB) measured at the end of the 5-year period by a hip-worn accelerometer for seven consecutive days. More GM (beta = 0.11; p = 0.044) and WM (beta = 0.11; p = 0.030) at baseline was associated with more total physical activity (TPA). Also, when adjusting for baseline values, the 5-year change in GM (beta = 0.14; p = 0.0037) and WM (beta = 0.11; p = 0.030) was associated with TPA. The 5-year change in WM was associated with SB (p = 0.11; p = 0.0007). These data suggest that objectively measured PA and SB late in life are associated with current and prior cross-sectional measures of brain atrophy, and that change over time is associated with PA and SB in expected directions.

Original languageEnglish
Pages (from-to)118-124
Number of pages7
JournalBehavioural Brain Research
Volume296
DOIs
Publication statusPublished - 1 Jan 2016

Keywords

  • Physical activity
  • Sedentary behavior
  • Brain atrophy
  • Elderly
  • MRI
  • WHITE-MATTER
  • COGNITIVE FUNCTION
  • TISSUE VOLUMES
  • UNITED-STATES
  • ATROPHY
  • HEALTH
  • RISK
  • POPULATION
  • PATTERNS
  • DECLINE

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