Association of Cerebrospinal Fluid (CSF) Insulin with Cognitive Performance and CSF Biomarkers of Alzheimer's Disease

Stefan L. C. Geijselaers, Pauline Aalten, Inez H. G. B. Ramakers, Peter Paul De Deyn, Annemieke C. Heijboer, Huiberdina L. Koek, Marcel G. M. OldeRikkert, Janne M. Papma, Fransje E. Reesink, Lieke L. Smits, Coen D. A. Stehouwer, Charlotte E. Teunissen, Frans R. J. Verhey, Wiesje M. van der Flier, Geert Jan Biessels,

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)309-320
Number of pages12
JournalJournal of Alzheimer's Disease
Volume61
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Alzheimer's disease
  • cerebrospinal fluid
  • cognition
  • epidemiology
  • insulin
  • IMPAIRED OLDER-ADULTS
  • INTRANASAL INSULIN
  • GLUCOSE-METABOLISM
  • DIFFERENTIAL SENSITIVITY
  • RESISTANCE SYNDROME
  • IMPROVES COGNITION
  • APOE GENOTYPE
  • TAU-PROTEIN
  • MEMORY
  • BRAIN
  • Humans
  • Middle Aged
  • Male
  • tau Proteins/cerebrospinal fluid
  • Cognition Disorders/diagnosis
  • Apolipoprotein E4/genetics
  • Mental Status Schedule
  • Female
  • Signal Transduction/genetics
  • Insulin/cerebrospinal fluid
  • Peptide Fragments/cerebrospinal fluid
  • Amyloid beta-Peptides/cerebrospinal fluid
  • Neuropsychological Tests
  • Alzheimer Disease/cerebrospinal fluid
  • Aged
  • Brain/metabolism
  • RISK
  • IMPAIRED INSULIN

Cite this

Geijselaers, S. L. C., Aalten, P., Ramakers, I. H. G. B., De Deyn, P. P., Heijboer, A. C., Koek, H. L., OldeRikkert, M. G. M., Papma, J. M., Reesink, F. E., Smits, L. L., Stehouwer, C. D. A., Teunissen, C. E., Verhey, F. R. J., van der Flier, W. M., Biessels, G. J. (2018). Association of Cerebrospinal Fluid (CSF) Insulin with Cognitive Performance and CSF Biomarkers of Alzheimer's Disease. Journal of Alzheimer's Disease, 61(1), 309-320. https://doi.org/10.3233/JAD-170522