Association of Cerebrospinal Fluid (CSF) Insulin with Cognitive Performance and CSF Biomarkers of Alzheimer's Disease

Stefan L. C. Geijselaers; Pauline Aalten; Inez H. G. B. Ramakers; Peter Paul De Deyn; Annemieke C. Heijboer; Huiberdina L. Koek; Marcel G. M. OldeRikkert; Janne M. Papma; Fransje E. Reesink; Lieke L. Smits; Coen D. A. Stehouwer; Charlotte E. Teunissen; Frans R. J. Verhey; Wiesje M. van der Flier; Geert Jan Biessels

doi:10.3233/JAD-170522

Association of Cerebrospinal Fluid (CSF) Insulin with Cognitive Performance and CSF Biomarkers of Alzheimer's Disease

Stefan L. C. Geijselaers, Pauline Aalten, Inez H. G. B. Ramakers, Peter Paul De Deyn, Annemieke C. Heijboer, Huiberdina L. Koek, Marcel G. M. OldeRikkert, Janne M. Papma, Fransje E. Reesink, Lieke L. Smits, Coen D. A. Stehouwer, Charlotte E. Teunissen, Frans R. J. Verhey, Wiesje M. van der Flier, Geert Jan Biessels,

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	309-320
Number of pages	12
Journal	Journal of Alzheimer's Disease
Volume	61
Issue number	1
DOIs	https://doi.org/10.3233/JAD-170522
Publication status	Published - 1 Jan 2018

Keywords

Alzheimer's disease
cerebrospinal fluid
cognition
epidemiology
insulin
IMPAIRED OLDER-ADULTS
INTRANASAL INSULIN
GLUCOSE-METABOLISM
DIFFERENTIAL SENSITIVITY
RESISTANCE SYNDROME
IMPROVES COGNITION
APOE GENOTYPE
TAU-PROTEIN
MEMORY
BRAIN
Humans
Middle Aged
Male
tau Proteins/cerebrospinal fluid
Cognition Disorders/diagnosis
Apolipoprotein E4/genetics
Mental Status Schedule
Female
Signal Transduction/genetics
Insulin/cerebrospinal fluid
Peptide Fragments/cerebrospinal fluid
Amyloid beta-Peptides/cerebrospinal fluid
Neuropsychological Tests
Alzheimer Disease/cerebrospinal fluid
Aged
Brain/metabolism
RISK
IMPAIRED INSULIN

Cite this

Geijselaers, S. L. C., Aalten, P., Ramakers, I. H. G. B., De Deyn, P. P., Heijboer, A. C., Koek, H. L., OldeRikkert, M. G. M., Papma, J. M., Reesink, F. E., Smits, L. L., Stehouwer, C. D. A., Teunissen, C. E., Verhey, F. R. J., van der Flier, W. M., Biessels, G. J. (2018). Association of Cerebrospinal Fluid (CSF) Insulin with Cognitive Performance and CSF Biomarkers of Alzheimer's Disease. Journal of Alzheimer's Disease, 61(1), 309-320. https://doi.org/10.3233/JAD-170522

Geijselaers, Stefan L. C. ; Aalten, Pauline ; Ramakers, Inez H. G. B. ; De Deyn, Peter Paul ; Heijboer, Annemieke C. ; Koek, Huiberdina L. ; OldeRikkert, Marcel G. M. ; Papma, Janne M. ; Reesink, Fransje E. ; Smits, Lieke L. ; Stehouwer, Coen D. A. ; Teunissen, Charlotte E. ; Verhey, Frans R. J. ; van der Flier, Wiesje M. ; Biessels, Geert Jan. / Association of Cerebrospinal Fluid (CSF) Insulin with Cognitive Performance and CSF Biomarkers of Alzheimer's Disease. In: Journal of Alzheimer's Disease. 2018 ; Vol. 61, No. 1. pp. 309-320.

@article{685166e94b924037b520bdc3023ea29a,

title = "Association of Cerebrospinal Fluid (CSF) Insulin with Cognitive Performance and CSF Biomarkers of Alzheimer's Disease",

keywords = "Alzheimer's disease, cerebrospinal fluid, cognition, epidemiology, insulin, IMPAIRED OLDER-ADULTS, INTRANASAL INSULIN, GLUCOSE-METABOLISM, DIFFERENTIAL SENSITIVITY, RESISTANCE SYNDROME, IMPROVES COGNITION, APOE GENOTYPE, TAU-PROTEIN, MEMORY, BRAIN, Humans, Middle Aged, Male, tau Proteins/cerebrospinal fluid, Cognition Disorders/diagnosis, Apolipoprotein E4/genetics, Mental Status Schedule, Female, Signal Transduction/genetics, Insulin/cerebrospinal fluid, Peptide Fragments/cerebrospinal fluid, Amyloid beta-Peptides/cerebrospinal fluid, Neuropsychological Tests, Alzheimer Disease/cerebrospinal fluid, Aged, Brain/metabolism, RISK, IMPAIRED INSULIN",

author = "Geijselaers, {Stefan L. C.} and Pauline Aalten and Ramakers, {Inez H. G. B.} and {De Deyn}, {Peter Paul} and Heijboer, {Annemieke C.} and Koek, {Huiberdina L.} and OldeRikkert, {Marcel G. M.} and Papma, {Janne M.} and Reesink, {Fransje E.} and Smits, {Lieke L.} and Stehouwer, {Coen D. A.} and Teunissen, {Charlotte E.} and Verhey, {Frans R. J.} and {van der Flier}, {Wiesje M.} and Biessels, {Geert Jan}",

year = "2018",

month = jan

day = "1",

doi = "10.3233/JAD-170522",

language = "English",

volume = "61",

pages = "309--320",

journal = "Journal of Alzheimer's Disease",

issn = "1387-2877",

publisher = "IOS Press",

number = "1",

}

Geijselaers, SLC, Aalten, P , Ramakers, IHGB, De Deyn, PP, Heijboer, AC, Koek, HL, OldeRikkert, MGM, Papma, JM, Reesink, FE, Smits, LL, Stehouwer, CDA, Teunissen, CE, Verhey, FRJ, van der Flier, WM, Biessels, GJ 2018, 'Association of Cerebrospinal Fluid (CSF) Insulin with Cognitive Performance and CSF Biomarkers of Alzheimer's Disease', Journal of Alzheimer's Disease, vol. 61, no. 1, pp. 309-320. https://doi.org/10.3233/JAD-170522

Association of Cerebrospinal Fluid (CSF) Insulin with Cognitive Performance and CSF Biomarkers of Alzheimer's Disease. / Geijselaers, Stefan L. C.; Aalten, Pauline ; Ramakers, Inez H. G. B.; De Deyn, Peter Paul; Heijboer, Annemieke C.; Koek, Huiberdina L.; OldeRikkert, Marcel G. M.; Papma, Janne M.; Reesink, Fransje E.; Smits, Lieke L.; Stehouwer, Coen D. A.; Teunissen, Charlotte E.; Verhey, Frans R. J.; van der Flier, Wiesje M.; Biessels, Geert Jan.

In: Journal of Alzheimer's Disease, Vol. 61, No. 1, 01.01.2018, p. 309-320.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Association of Cerebrospinal Fluid (CSF) Insulin with Cognitive Performance and CSF Biomarkers of Alzheimer's Disease

AU - Geijselaers, Stefan L. C.

AU - Aalten, Pauline

AU - Ramakers, Inez H. G. B.

AU - De Deyn, Peter Paul

AU - Heijboer, Annemieke C.

AU - Koek, Huiberdina L.

AU - OldeRikkert, Marcel G. M.

AU - Papma, Janne M.

AU - Reesink, Fransje E.

AU - Smits, Lieke L.

AU - Stehouwer, Coen D. A.

AU - Teunissen, Charlotte E.

AU - Verhey, Frans R. J.

AU - van der Flier, Wiesje M.

AU - Biessels, Geert Jan

PY - 2018/1/1

Y1 - 2018/1/1

KW - Alzheimer's disease

KW - cerebrospinal fluid

KW - cognition

KW - epidemiology

KW - insulin

KW - IMPAIRED OLDER-ADULTS

KW - INTRANASAL INSULIN

KW - GLUCOSE-METABOLISM

KW - DIFFERENTIAL SENSITIVITY

KW - RESISTANCE SYNDROME

KW - IMPROVES COGNITION

KW - APOE GENOTYPE

KW - TAU-PROTEIN

KW - MEMORY

KW - BRAIN

KW - Humans

KW - Middle Aged

KW - Male

KW - tau Proteins/cerebrospinal fluid

KW - Cognition Disorders/diagnosis

KW - Apolipoprotein E4/genetics

KW - Mental Status Schedule

KW - Female

KW - Signal Transduction/genetics

KW - Insulin/cerebrospinal fluid

KW - Peptide Fragments/cerebrospinal fluid

KW - Amyloid beta-Peptides/cerebrospinal fluid

KW - Neuropsychological Tests

KW - Alzheimer Disease/cerebrospinal fluid

KW - Aged

KW - Brain/metabolism

KW - RISK

KW - IMPAIRED INSULIN

U2 - 10.3233/JAD-170522

DO - 10.3233/JAD-170522

M3 - Article

VL - 61

SP - 309

EP - 320

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

IS - 1

ER -

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