TY - JOUR
T1 - Association of artificially sweetened and sugar-sweetened soft drinks with β-cell function, insulin sensitivity, and type 2 diabetes
T2 - the Maastricht Study
AU - den Biggelaar, Louise J C J
AU - Sep, Simone J S
AU - Mari, Andrea
AU - Ferrannini, Ele
AU - van Dongen, Martien C J M
AU - Wijckmans, Nicole E G
AU - Schram, Miranda T
AU - van der Kallen, Carla J
AU - Schaper, Nicolaas
AU - Henry, Ronald M A
AU - van Greevenbroek, Marleen M
AU - Stehouwer, Coen D A
AU - Eussen, Simone J P M
N1 - Funding Information:
This study was supported by the European Regional Development Fund via OP-Zuid, the Province of Limburg, the Dutch Ministry of Economic Affairs (Grant 31O.041), Stichting De Weijerhorst (Maastricht, The Netherlands), the Pearl String Initiative Diabetes (Amsterdam, The Netherlands), the Cardiovascular Center (CVC, Maastricht, The Netherlands), CARIM School for Cardiovascular Diseases (Maastricht, The Netherlands), CAPHRI School for Public Health and Primary Care (Maastricht, The Netherlands), NUTRIM School for Nutrition and Translational Research in Metabolism (Maastricht, The Netherlands), Stichting Annadal (Maastricht, The Netherlands), Health Foundation Limburg (Maastricht, The Netherlands) and by unrestricted grants from Janssen-Cilag B.V. (Tilburg, The Netherlands), Novo Nordisk Farma B.V. (Alphen aan den Rijn, The Netherlands) and Sanofi-Aventis Netherlands B.V. (Gouda, The Netherlands). Acknowledgements
Publisher Copyright:
© 2019, The Author(s).
PY - 2020/6
Y1 - 2020/6
N2 - PURPOSE: Artificially sweetened and sugar-sweetened beverage consumptions have both been reported to be associated with type 2 diabetes mellitus (T2D) risk. The aim of the current study was to investigate the potential underlying associations with dynamic pancreatic β-cell function (BCF) and insulin sensitivity.METHODS: We evaluated cross-sectional associations in 2240 individuals (mean ± SD age 59.6 ± 8.18, 49.4% male, 21.9% T2D) participating in a diabetes-enriched population-based cohort. Artificially sweetened and sugar-sweetened soft drinks and juice consumption were assessed by a food-frequency questionnaire. Glucose metabolism status, insulin sensitivity, and BCF were measured by a seven-point oral glucose tolerance test. Regression analyses were performed to assess associations of artificially and sugar-sweetened beverage consumption with measures of glucose homeostasis. Associations were adjusted for potential confounders, and additionally with and without total energy intake and BMI, as these variables could be mediators.RESULTS: Moderate consumption of artificially sweetened soft drink was associated with lower β-cell glucose sensitivity [standardized beta (95% CI), - 0.06 (- 0.11, - 0.02)], total insulin secretion [β - 0.06 (- 0.10, - 0.02)], and with lower β-cell rate sensitivity [odds ratio (95% CI), 1.29 (1.03, 1.62)] compared to abstainers. Daily artificially sweetened soft drink consumption was associated with lower β-cell glucose sensitivity [β - 0.05 (- 0.09, 0.00)], and total insulin secretion [β - 0.05 - 0.09, - 0.01)] compared to abstainers.CONCLUSIONS: Moderate and daily consumption of artificially sweetened soft drinks was associated with lower BCF, but not with insulin sensitivity. No evidence was found for associations of sugar-sweetened soft drink and juice consumption with BCF or insulin sensitivity in this middle-aged population. Prospective studies are warranted to further investigate the associations of artificially and sugar-sweetened beverage consumption with non-fasting insulin sensitivity and multiple BCF aspects.
AB - PURPOSE: Artificially sweetened and sugar-sweetened beverage consumptions have both been reported to be associated with type 2 diabetes mellitus (T2D) risk. The aim of the current study was to investigate the potential underlying associations with dynamic pancreatic β-cell function (BCF) and insulin sensitivity.METHODS: We evaluated cross-sectional associations in 2240 individuals (mean ± SD age 59.6 ± 8.18, 49.4% male, 21.9% T2D) participating in a diabetes-enriched population-based cohort. Artificially sweetened and sugar-sweetened soft drinks and juice consumption were assessed by a food-frequency questionnaire. Glucose metabolism status, insulin sensitivity, and BCF were measured by a seven-point oral glucose tolerance test. Regression analyses were performed to assess associations of artificially and sugar-sweetened beverage consumption with measures of glucose homeostasis. Associations were adjusted for potential confounders, and additionally with and without total energy intake and BMI, as these variables could be mediators.RESULTS: Moderate consumption of artificially sweetened soft drink was associated with lower β-cell glucose sensitivity [standardized beta (95% CI), - 0.06 (- 0.11, - 0.02)], total insulin secretion [β - 0.06 (- 0.10, - 0.02)], and with lower β-cell rate sensitivity [odds ratio (95% CI), 1.29 (1.03, 1.62)] compared to abstainers. Daily artificially sweetened soft drink consumption was associated with lower β-cell glucose sensitivity [β - 0.05 (- 0.09, 0.00)], and total insulin secretion [β - 0.05 - 0.09, - 0.01)] compared to abstainers.CONCLUSIONS: Moderate and daily consumption of artificially sweetened soft drinks was associated with lower BCF, but not with insulin sensitivity. No evidence was found for associations of sugar-sweetened soft drink and juice consumption with BCF or insulin sensitivity in this middle-aged population. Prospective studies are warranted to further investigate the associations of artificially and sugar-sweetened beverage consumption with non-fasting insulin sensitivity and multiple BCF aspects.
KW - Artificially sweetened beverages
KW - Sugar-sweetened beverages
KW - Soft drink
KW - Juice
KW - Beta-cell function
KW - Insulin sensitivity
KW - T2D
KW - ORAL GLUCOSE-TOLERANCE
KW - DIET SODA CONSUMPTION
KW - BEVERAGE CONSUMPTION
KW - METABOLIC SYNDROME
KW - RISK
KW - RESISTANCE
KW - MIDDLE
KW - MELLITUS
KW - METAANALYSIS
KW - OVERWEIGHT
U2 - 10.1007/s00394-019-02026-0
DO - 10.1007/s00394-019-02026-0
M3 - Article
C2 - 31486878
SN - 1436-6207
VL - 59
SP - 1717
EP - 1727
JO - European Journal of Nutrition
JF - European Journal of Nutrition
IS - 4
ER -