Association of a NOS3 gene polymorphism with Behcet's disease but not with Vogt-Koyanagi-Harada syndrome in Han Chinese

Yan Zhou, Hongsong Yu, Shengping Hou, Jing Fang, Jieying Qin, Gangxiang Yuan, Aize Kijlstra, Peizeng Yang*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Purpose: Previous studies have identified that nitric oxide synthase (NOS) genes are associated with several immune-mediated diseases. This study aimed to investigate whether NOS2 and NOS3 gene polymorphisms are associated with Behcet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome in a Han Chinese population.Methods: An association analysis of NOS2/rs4795067, NOS3/rs1799983 and NOS3/rs1800779 was performed in 733 patients with BD, 800 patients with VKH syndrome, and 1,359 controls using PCR restriction fragment length polymorphism (PCR-RFLP) assay. Statistical analysis was performed with the chi-square test followed by the Bonferroni correction.Results: The result showed a decreased frequency of the NOS3/rs1799983 GG genotype and an increased frequency of NOS3/rs1799983 GT genotype in the patients with BD (Bonferroni correction test [Pc]=0.02, odds ratio [OR]=0.74; Pc=2.1x10(-3), OR=1.57, respectively). No significant association was found between rs1799983 and VKH syndrome. NOS2/rs4795067 and NOS3/rs1800779 were not associated with either BD or VKH syndrome.Conclusions: Our findings suggest that a NOS3/rs1799983polymorphism is associated with susceptibility to BD in Han Chinese.
Original languageEnglish
Pages (from-to)311-318
JournalMolecular Vision
Publication statusPublished - 3 Apr 2016


  • Adult
  • Asian People/genetics
  • Behcet Syndrome/diagnosis genetics
  • Case-Control Studies
  • China/epidemiology
  • Female
  • Gene Frequency
  • Genotyping Techniques
  • Humans
  • Male
  • Nitric Oxide Synthase Type II/genetics
  • Nitric Oxide Synthase Type III/genetics
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length
  • Polymorphism, Single Nucleotide
  • Uveomeningoencephalitic Syndrome/diagnosis genetics
  • Young Adult


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