Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder

GRP Investigators G, Jim van Os

Research output: Contribution to journalArticleAcademicpeer-review

55 Citations (Web of Science)

Abstract

A recent study found genome-wide significant association between common variation in the gene neurocan (NCAN, rs1064395) and bipolar disorder (BD). In view of accumulating evidence that BD and schizophrenia partly share genetic risk factors, we tested this single-nucleotide polymorphism for association with schizophrenia in three independent patient-control samples of European ancestry, totaling 5061 patients and 9655 controls. The rs1064395 A-allele, which confers risk for BD, was significantly over-represented in schizophrenia patients compared to controls (p=2.28?10(-3); odds ratio=1.11). Follow-up in non-overlapping samples from the Schizophrenia Psychiatric GWAS Consortium (5537 patients, 8043 controls) provided further support for our finding (p=0.0239, odds ratio=1.07). Our data suggest that genetic variation in NCAN is a common risk factor for BD and schizophrenia.
Original languageEnglish
Pages (from-to)69-73
JournalSchizophrenia Research
Volume138
Issue number1
DOIs
Publication statusPublished - Jun 2012

Keywords

  • Association
  • Genetic overlap
  • Manic depression
  • Psychotic disorder
  • Cortex
  • Hippocampus

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