Association between pre hemodialysis serum sodium concentration and blood pressure: results from a retrospective analysis from the international monitoring dialysis outcomes (MONDO) initiative

J.G. Raimann, B. Canaud, M. Etter, J.P. Kooman, N.W. Levin, D. Marcelli, C. Marelli, A. Power, N. Duncan, F.M. van der Sande, P. Carioni, S. Thijssen, X. Xu, L.A. Usvyat, Y. Wang, P. Kotanko

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

A recent study from the United Kingdom indicates an association between pre hemodialysis (HD) serum sodium (SNa+) and systolic and diastolic blood pressure (SBP and DBP) in chronic HD patients. We extend this analysis to an international cohort of incident HD patients. The Monitoring Dialysis Outcomes initiative encompasses patients from 41 countries. Over 2 years monthly pre-HD SNa+ levels were used as predictors of pre-HD SBP and DBP in a linear mixed model (LMM) adjusted for age, gender, interdialytic weight gain, diabetes, serum albumin and calcium. Similar models were constructed with DBP as outcome. Analyses were carried out stratified by continent (North and South America; Europe and Asia). LMMs were also constructed for the entire observation period of 2 years, and separately the first and the second year after HD initiation. We studied 17 050 incident patients and found SNa+ to have a significant slope estimate in the LMM predicting pre-HD SBP and DBP (ranging from 0.22 to 0.29 and 0.10 to 0.21 mm Hg per mEq l-1, respectively, between the continents). The findings were similar in subsets of SBP and SNa+ tertiles, and separately analyzed for the first and second year. Our analysis shows an independent association between SNa, SBP and DBP in a large intercontinental database, indicating that this relation is a profound biological phenomenon in incident and prevalent HD patients, generalizable to an international level and independent of SBP and DBP magnitude.Journal of Human Hypertension advance online publication, 30 July 2015; doi:10.1038/jhh.2015.79.
Original languageEnglish
Pages (from-to)442-448
Number of pages7
JournalJournal of Human Hypertension
Volume30
Issue number7
DOIs
Publication statusPublished - Jul 2016

Keywords

  • INTERDIALYTIC WEIGHT-GAIN
  • NITRIC-OXIDE SYNTHASE
  • LEFT-VENTRICULAR MASS
  • HUMAN ENDOTHELIUM
  • PLASMA SODIUM
  • SALT SENSITIVITY
  • DIETARY-SODIUM
  • HYPERTENSION
  • ALDOSTERONE
  • GLUCOSE

Cite this

Raimann, J.G. ; Canaud, B. ; Etter, M. ; Kooman, J.P. ; Levin, N.W. ; Marcelli, D. ; Marelli, C. ; Power, A. ; Duncan, N. ; van der Sande, F.M. ; Carioni, P. ; Thijssen, S. ; Xu, X. ; Usvyat, L.A. ; Wang, Y. ; Kotanko, P. / Association between pre hemodialysis serum sodium concentration and blood pressure: results from a retrospective analysis from the international monitoring dialysis outcomes (MONDO) initiative. In: Journal of Human Hypertension. 2016 ; Vol. 30, No. 7. pp. 442-448.
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abstract = "A recent study from the United Kingdom indicates an association between pre hemodialysis (HD) serum sodium (SNa+) and systolic and diastolic blood pressure (SBP and DBP) in chronic HD patients. We extend this analysis to an international cohort of incident HD patients. The Monitoring Dialysis Outcomes initiative encompasses patients from 41 countries. Over 2 years monthly pre-HD SNa+ levels were used as predictors of pre-HD SBP and DBP in a linear mixed model (LMM) adjusted for age, gender, interdialytic weight gain, diabetes, serum albumin and calcium. Similar models were constructed with DBP as outcome. Analyses were carried out stratified by continent (North and South America; Europe and Asia). LMMs were also constructed for the entire observation period of 2 years, and separately the first and the second year after HD initiation. We studied 17 050 incident patients and found SNa+ to have a significant slope estimate in the LMM predicting pre-HD SBP and DBP (ranging from 0.22 to 0.29 and 0.10 to 0.21 mm Hg per mEq l-1, respectively, between the continents). The findings were similar in subsets of SBP and SNa+ tertiles, and separately analyzed for the first and second year. Our analysis shows an independent association between SNa, SBP and DBP in a large intercontinental database, indicating that this relation is a profound biological phenomenon in incident and prevalent HD patients, generalizable to an international level and independent of SBP and DBP magnitude.Journal of Human Hypertension advance online publication, 30 July 2015; doi:10.1038/jhh.2015.79.",
keywords = "INTERDIALYTIC WEIGHT-GAIN, NITRIC-OXIDE SYNTHASE, LEFT-VENTRICULAR MASS, HUMAN ENDOTHELIUM, PLASMA SODIUM, SALT SENSITIVITY, DIETARY-SODIUM, HYPERTENSION, ALDOSTERONE, GLUCOSE",
author = "J.G. Raimann and B. Canaud and M. Etter and J.P. Kooman and N.W. Levin and D. Marcelli and C. Marelli and A. Power and N. Duncan and {van der Sande}, F.M. and P. Carioni and S. Thijssen and X. Xu and L.A. Usvyat and Y. Wang and P. Kotanko",
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Raimann, JG, Canaud, B, Etter, M, Kooman, JP, Levin, NW, Marcelli, D, Marelli, C, Power, A, Duncan, N, van der Sande, FM, Carioni, P, Thijssen, S, Xu, X, Usvyat, LA, Wang, Y & Kotanko, P 2016, 'Association between pre hemodialysis serum sodium concentration and blood pressure: results from a retrospective analysis from the international monitoring dialysis outcomes (MONDO) initiative', Journal of Human Hypertension, vol. 30, no. 7, pp. 442-448. https://doi.org/10.1038/jhh.2015.79

Association between pre hemodialysis serum sodium concentration and blood pressure: results from a retrospective analysis from the international monitoring dialysis outcomes (MONDO) initiative. / Raimann, J.G.; Canaud, B.; Etter, M.; Kooman, J.P.; Levin, N.W.; Marcelli, D.; Marelli, C.; Power, A.; Duncan, N.; van der Sande, F.M.; Carioni, P.; Thijssen, S.; Xu, X.; Usvyat, L.A.; Wang, Y.; Kotanko, P.

In: Journal of Human Hypertension, Vol. 30, No. 7, 07.2016, p. 442-448.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Association between pre hemodialysis serum sodium concentration and blood pressure: results from a retrospective analysis from the international monitoring dialysis outcomes (MONDO) initiative

AU - Raimann, J.G.

AU - Canaud, B.

AU - Etter, M.

AU - Kooman, J.P.

AU - Levin, N.W.

AU - Marcelli, D.

AU - Marelli, C.

AU - Power, A.

AU - Duncan, N.

AU - van der Sande, F.M.

AU - Carioni, P.

AU - Thijssen, S.

AU - Xu, X.

AU - Usvyat, L.A.

AU - Wang, Y.

AU - Kotanko, P.

PY - 2016/7

Y1 - 2016/7

N2 - A recent study from the United Kingdom indicates an association between pre hemodialysis (HD) serum sodium (SNa+) and systolic and diastolic blood pressure (SBP and DBP) in chronic HD patients. We extend this analysis to an international cohort of incident HD patients. The Monitoring Dialysis Outcomes initiative encompasses patients from 41 countries. Over 2 years monthly pre-HD SNa+ levels were used as predictors of pre-HD SBP and DBP in a linear mixed model (LMM) adjusted for age, gender, interdialytic weight gain, diabetes, serum albumin and calcium. Similar models were constructed with DBP as outcome. Analyses were carried out stratified by continent (North and South America; Europe and Asia). LMMs were also constructed for the entire observation period of 2 years, and separately the first and the second year after HD initiation. We studied 17 050 incident patients and found SNa+ to have a significant slope estimate in the LMM predicting pre-HD SBP and DBP (ranging from 0.22 to 0.29 and 0.10 to 0.21 mm Hg per mEq l-1, respectively, between the continents). The findings were similar in subsets of SBP and SNa+ tertiles, and separately analyzed for the first and second year. Our analysis shows an independent association between SNa, SBP and DBP in a large intercontinental database, indicating that this relation is a profound biological phenomenon in incident and prevalent HD patients, generalizable to an international level and independent of SBP and DBP magnitude.Journal of Human Hypertension advance online publication, 30 July 2015; doi:10.1038/jhh.2015.79.

AB - A recent study from the United Kingdom indicates an association between pre hemodialysis (HD) serum sodium (SNa+) and systolic and diastolic blood pressure (SBP and DBP) in chronic HD patients. We extend this analysis to an international cohort of incident HD patients. The Monitoring Dialysis Outcomes initiative encompasses patients from 41 countries. Over 2 years monthly pre-HD SNa+ levels were used as predictors of pre-HD SBP and DBP in a linear mixed model (LMM) adjusted for age, gender, interdialytic weight gain, diabetes, serum albumin and calcium. Similar models were constructed with DBP as outcome. Analyses were carried out stratified by continent (North and South America; Europe and Asia). LMMs were also constructed for the entire observation period of 2 years, and separately the first and the second year after HD initiation. We studied 17 050 incident patients and found SNa+ to have a significant slope estimate in the LMM predicting pre-HD SBP and DBP (ranging from 0.22 to 0.29 and 0.10 to 0.21 mm Hg per mEq l-1, respectively, between the continents). The findings were similar in subsets of SBP and SNa+ tertiles, and separately analyzed for the first and second year. Our analysis shows an independent association between SNa, SBP and DBP in a large intercontinental database, indicating that this relation is a profound biological phenomenon in incident and prevalent HD patients, generalizable to an international level and independent of SBP and DBP magnitude.Journal of Human Hypertension advance online publication, 30 July 2015; doi:10.1038/jhh.2015.79.

KW - INTERDIALYTIC WEIGHT-GAIN

KW - NITRIC-OXIDE SYNTHASE

KW - LEFT-VENTRICULAR MASS

KW - HUMAN ENDOTHELIUM

KW - PLASMA SODIUM

KW - SALT SENSITIVITY

KW - DIETARY-SODIUM

KW - HYPERTENSION

KW - ALDOSTERONE

KW - GLUCOSE

U2 - 10.1038/jhh.2015.79

DO - 10.1038/jhh.2015.79

M3 - Article

VL - 30

SP - 442

EP - 448

JO - Journal of Human Hypertension

JF - Journal of Human Hypertension

SN - 0950-9240

IS - 7

ER -