Association between polyunsaturated fatty acid concentrations in maternal plasma phospholipids during pregnancy and offspring adiposity at age 7: The MEFAB cohort.

P.S. de Vries; M. Gielen; D. Rizopoulos; P. Rump; R. Godschalk; G. Hornstra; M.P. Zeegers

doi:10.1016/j.plefa.2014.04.002

Association between polyunsaturated fatty acid concentrations in maternal plasma phospholipids during pregnancy and offspring adiposity at age 7: The MEFAB cohort.

P.S. de Vries, M. Gielen^*, D. Rizopoulos, P. Rump, R. Godschalk, G. Hornstra, M.P. Zeegers

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Prenatal polyunsaturated fatty acid (PUFA) concentrations may be involved in the prenatal programming of adiposity. In this study we therefore explored the association between maternal PUFA concentrations, measured up to four times during pregnancy, and offspring adiposity at age 7 in 234 mother-child pairs of the Maastricht Essential Fatty Acid Birth cohort. Only dihomo-gamma-linolenic acid (DGLA, an n-6 fatty acid) concentration was associated with adiposity: per standard deviation increase in relative DGLA concentration, BMI increased by 0.44kg/m2 (CI95: 0.16, 0.72), sum of skinfolds increased by 3.41mm (CI95: 1.88, 4.95), waist circumference increased by 1.09cm (CI95: 0.40, 1.78), and plasma leptin concentration increased by 0.66microg/l (CI95: 0.20, 1.11). In conclusion, maternal DGLA throughout gestation was associated with increased BMI and some additional measures of adiposity at age 7. This suggests that maternal DGLA might play a role in or reflect the prenatal programming of adiposity.

Original language	English
Pages (from-to)	81-85
Number of pages	5
Journal	Prostaglandins Leukotrienes and Essential Fatty Acids
Volume	91
Issue number	3
DOIs	https://doi.org/10.1016/j.plefa.2014.04.002
Publication status	Published - Sept 2014

Keywords

Prental programming
Fetal origins
Essential fatty acids
Polyunsaturated fatty acids
Childhood adiposity
Childhood obesity
BODY-COMPOSITION
TISSUE DEVELOPMENT
ARACHIDONIC-ACID
OBESE CHILDREN
N-6
DIFFERENTIATION
CHILDHOOD
ORIGINS
WEIGHT
INFANT

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de Vries, P. S., Gielen, M., Rizopoulos, D., Rump, P., Godschalk, R., Hornstra, G., & Zeegers, M. P. (2014). Association between polyunsaturated fatty acid concentrations in maternal plasma phospholipids during pregnancy and offspring adiposity at age 7: The MEFAB cohort. Prostaglandins Leukotrienes and Essential Fatty Acids, 91(3), 81-85. https://doi.org/10.1016/j.plefa.2014.04.002

@article{baaf7e7b6e174b878131c386372ada7a,

title = "Association between polyunsaturated fatty acid concentrations in maternal plasma phospholipids during pregnancy and offspring adiposity at age 7: The MEFAB cohort.",

abstract = "Prenatal polyunsaturated fatty acid (PUFA) concentrations may be involved in the prenatal programming of adiposity. In this study we therefore explored the association between maternal PUFA concentrations, measured up to four times during pregnancy, and offspring adiposity at age 7 in 234 mother-child pairs of the Maastricht Essential Fatty Acid Birth cohort. Only dihomo-gamma-linolenic acid (DGLA, an n-6 fatty acid) concentration was associated with adiposity: per standard deviation increase in relative DGLA concentration, BMI increased by 0.44kg/m2 (CI95: 0.16, 0.72), sum of skinfolds increased by 3.41mm (CI95: 1.88, 4.95), waist circumference increased by 1.09cm (CI95: 0.40, 1.78), and plasma leptin concentration increased by 0.66microg/l (CI95: 0.20, 1.11). In conclusion, maternal DGLA throughout gestation was associated with increased BMI and some additional measures of adiposity at age 7. This suggests that maternal DGLA might play a role in or reflect the prenatal programming of adiposity.",

keywords = "Prental programming, Fetal origins, Essential fatty acids, Polyunsaturated fatty acids, Childhood adiposity, Childhood obesity, BODY-COMPOSITION, TISSUE DEVELOPMENT, ARACHIDONIC-ACID, OBESE CHILDREN, N-6, DIFFERENTIATION, CHILDHOOD, ORIGINS, WEIGHT, INFANT",

author = "{de Vries}, P.S. and M. Gielen and D. Rizopoulos and P. Rump and R. Godschalk and G. Hornstra and M.P. Zeegers",

year = "2014",

month = sep,

doi = "10.1016/j.plefa.2014.04.002",

language = "English",

volume = "91",

pages = "81--85",

journal = "Prostaglandins Leukotrienes and Essential Fatty Acids",

issn = "0952-3278",

publisher = "ELSEVIER SCI LTD",

number = "3",

}

de Vries, PS, Gielen, M, Rizopoulos, D, Rump, P, Godschalk, R, Hornstra, G & Zeegers, MP 2014, 'Association between polyunsaturated fatty acid concentrations in maternal plasma phospholipids during pregnancy and offspring adiposity at age 7: The MEFAB cohort.', Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 91, no. 3, pp. 81-85. https://doi.org/10.1016/j.plefa.2014.04.002

Association between polyunsaturated fatty acid concentrations in maternal plasma phospholipids during pregnancy and offspring adiposity at age 7: The MEFAB cohort. / de Vries, P.S.; Gielen, M.; Rizopoulos, D. et al.
In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 91, No. 3, 09.2014, p. 81-85.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Association between polyunsaturated fatty acid concentrations in maternal plasma phospholipids during pregnancy and offspring adiposity at age 7: The MEFAB cohort.

AU - de Vries, P.S.

AU - Gielen, M.

AU - Rizopoulos, D.

AU - Rump, P.

AU - Godschalk, R.

AU - Hornstra, G.

AU - Zeegers, M.P.

PY - 2014/9

Y1 - 2014/9

N2 - Prenatal polyunsaturated fatty acid (PUFA) concentrations may be involved in the prenatal programming of adiposity. In this study we therefore explored the association between maternal PUFA concentrations, measured up to four times during pregnancy, and offspring adiposity at age 7 in 234 mother-child pairs of the Maastricht Essential Fatty Acid Birth cohort. Only dihomo-gamma-linolenic acid (DGLA, an n-6 fatty acid) concentration was associated with adiposity: per standard deviation increase in relative DGLA concentration, BMI increased by 0.44kg/m2 (CI95: 0.16, 0.72), sum of skinfolds increased by 3.41mm (CI95: 1.88, 4.95), waist circumference increased by 1.09cm (CI95: 0.40, 1.78), and plasma leptin concentration increased by 0.66microg/l (CI95: 0.20, 1.11). In conclusion, maternal DGLA throughout gestation was associated with increased BMI and some additional measures of adiposity at age 7. This suggests that maternal DGLA might play a role in or reflect the prenatal programming of adiposity.

AB - Prenatal polyunsaturated fatty acid (PUFA) concentrations may be involved in the prenatal programming of adiposity. In this study we therefore explored the association between maternal PUFA concentrations, measured up to four times during pregnancy, and offspring adiposity at age 7 in 234 mother-child pairs of the Maastricht Essential Fatty Acid Birth cohort. Only dihomo-gamma-linolenic acid (DGLA, an n-6 fatty acid) concentration was associated with adiposity: per standard deviation increase in relative DGLA concentration, BMI increased by 0.44kg/m2 (CI95: 0.16, 0.72), sum of skinfolds increased by 3.41mm (CI95: 1.88, 4.95), waist circumference increased by 1.09cm (CI95: 0.40, 1.78), and plasma leptin concentration increased by 0.66microg/l (CI95: 0.20, 1.11). In conclusion, maternal DGLA throughout gestation was associated with increased BMI and some additional measures of adiposity at age 7. This suggests that maternal DGLA might play a role in or reflect the prenatal programming of adiposity.

KW - Prental programming

KW - Fetal origins

KW - Essential fatty acids

KW - Polyunsaturated fatty acids

KW - Childhood adiposity

KW - Childhood obesity

KW - BODY-COMPOSITION

KW - TISSUE DEVELOPMENT

KW - ARACHIDONIC-ACID

KW - OBESE CHILDREN

KW - N-6

KW - DIFFERENTIATION

KW - CHILDHOOD

KW - ORIGINS

KW - WEIGHT

KW - INFANT

U2 - 10.1016/j.plefa.2014.04.002

DO - 10.1016/j.plefa.2014.04.002

M3 - Article

SN - 0952-3278

VL - 91

SP - 81

EP - 85

JO - Prostaglandins Leukotrienes and Essential Fatty Acids

JF - Prostaglandins Leukotrienes and Essential Fatty Acids

IS - 3

ER -

Association between polyunsaturated fatty acid concentrations in maternal plasma phospholipids during pregnancy and offspring adiposity at age 7: The MEFAB cohort.

Abstract

Keywords

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