TY - JOUR
T1 - Association between patient-reported outcomes and exercise test outcomes in patients with COPD before and after pulmonary rehabilitation
AU - Meys, Roy
AU - Stoffels, Anouk A. F.
AU - Houben-Wilke, Sarah
AU - Janssen, Daisy J. A.
AU - Burtin, Chris
AU - van Hees, Hieronymus W. H.
AU - Franssen, Frits M. E.
AU - van den Borst, Bram
AU - Wouters, Emiel F. M.
AU - Spruit, Martijn A.
AU - BASES Consortium
N1 - Funding Information:
The BASES project is supported by the Lung Foundation Netherlands (#5.1.18.232). The Chance project was supported by the Lung Foundation Netherlands (#3.4.10.015) and GlaxoSmithKline (SCO115406).
Publisher Copyright:
© 2020 The Author(s).
PY - 2020/9/5
Y1 - 2020/9/5
N2 - Background: Over the years, the scope of outcomes assessment in chronic obstructive pulmonary disease (COPD) has broadened, allowing for the evaluation of various patient-reported outcomes (PROs). As it still remains unclear whether and to what extent PROs mirror the exercise performance of patients with COPD, the current study aimed to assess the association between different exercise test outcomes and PROs, before and after pulmonary rehabilitation (PR).Methods: Correlations between PROs used to describe health-related quality of life (HRQoL), mood status, level of care dependency and dyspnea in patients with COPD and commonly used laboratory- and field-based exercise test outcomes were evaluated in 518 individuals with COPD attending PR.Results: Overall, correlations between PROs and exercise test outcomes at baseline were statistically significant. The correlation between modified Medical Research Council (mMRC) dyspnea score and 6-min walking distance (6MWD) was strongest (rho:-0.65;pConclusions: PROs and exercise test outcomes, although significantly correlated with each other, assess different disease features in patients with COPD. Individual PROs need to be supported by additional functional measurements whenever possible, in order to get a more detailed insight in the effectiveness of a PR program.
AB - Background: Over the years, the scope of outcomes assessment in chronic obstructive pulmonary disease (COPD) has broadened, allowing for the evaluation of various patient-reported outcomes (PROs). As it still remains unclear whether and to what extent PROs mirror the exercise performance of patients with COPD, the current study aimed to assess the association between different exercise test outcomes and PROs, before and after pulmonary rehabilitation (PR).Methods: Correlations between PROs used to describe health-related quality of life (HRQoL), mood status, level of care dependency and dyspnea in patients with COPD and commonly used laboratory- and field-based exercise test outcomes were evaluated in 518 individuals with COPD attending PR.Results: Overall, correlations between PROs and exercise test outcomes at baseline were statistically significant. The correlation between modified Medical Research Council (mMRC) dyspnea score and 6-min walking distance (6MWD) was strongest (rho:-0.65;pConclusions: PROs and exercise test outcomes, although significantly correlated with each other, assess different disease features in patients with COPD. Individual PROs need to be supported by additional functional measurements whenever possible, in order to get a more detailed insight in the effectiveness of a PR program.
KW - COPD
KW - Patient-reported outcome measures
KW - Exercise test
KW - Pulmonary rehabilitation
KW - Quality of life
KW - FIELD WALKING TESTS
KW - CARE DEPENDENCY
KW - GO TEST
KW - VALIDATION
KW - DISTANCE
U2 - 10.1186/s12955-020-01505-x
DO - 10.1186/s12955-020-01505-x
M3 - Article
C2 - 32891156
SN - 1477-7525
VL - 18
JO - Health and Quality of Life Outcomes
JF - Health and Quality of Life Outcomes
IS - 1
M1 - 300
ER -