Association between patient-reported outcomes and exercise test outcomes in patients with COPD before and after pulmonary rehabilitation

Roy Meys*, Anouk A. F. Stoffels, Sarah Houben-Wilke, Daisy J. A. Janssen, Chris Burtin, Hieronymus W. H. van Hees, Frits M. E. Franssen, Bram van den Borst, Emiel F. M. Wouters, Martijn A. Spruit, BASES Consortium

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Web of Science)


Background: Over the years, the scope of outcomes assessment in chronic obstructive pulmonary disease (COPD) has broadened, allowing for the evaluation of various patient-reported outcomes (PROs). As it still remains unclear whether and to what extent PROs mirror the exercise performance of patients with COPD, the current study aimed to assess the association between different exercise test outcomes and PROs, before and after pulmonary rehabilitation (PR).

Methods: Correlations between PROs used to describe health-related quality of life (HRQoL), mood status, level of care dependency and dyspnea in patients with COPD and commonly used laboratory- and field-based exercise test outcomes were evaluated in 518 individuals with COPD attending PR.

Results: Overall, correlations between PROs and exercise test outcomes at baseline were statistically significant. The correlation between modified Medical Research Council (mMRC) dyspnea score and 6-min walking distance (6MWD) was strongest (rho:-0.65;p

Conclusions: PROs and exercise test outcomes, although significantly correlated with each other, assess different disease features in patients with COPD. Individual PROs need to be supported by additional functional measurements whenever possible, in order to get a more detailed insight in the effectiveness of a PR program.

Original languageEnglish
Article number300
Number of pages9
JournalHealth and Quality of Life Outcomes
Issue number1
Publication statusPublished - 5 Sep 2020


  • COPD
  • Patient-reported outcome measures
  • Exercise test
  • Pulmonary rehabilitation
  • Quality of life

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