Association Between Occupational, Sport, and Leisure Related Physical Activity and Baroreflex Sensitivity The Paris Prospective Study III

Rachel E. Climie*, Pierre Boutouyrie, Marie-Cecile Perier, Edouard Chaussade, Mattieu Plichart, Lucile Offredo, Catherine Guibout, Thomas T. van Sloten, Frederique Thomas, Bruno Pannier, James E. Sharman, Stephane Laurent, Xavier Jouven, Jean-Philippe Empana

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

196 Downloads (Pure)

Abstract

Physical activity (PA) is a preventative behavior for noncommunicable disease. However, little consideration is given as to whether different domains of PA have differing associations with health outcomes. We sought to determine the association between occupational, sport, leisure, and total PA with baroreflex sensitivity (BRS), distinguishing between neural (nBRS) and mechanical (mBRS) BRS. In a cross-sectional analysis of 8649 adults aged 50 to 75 years, resting nBRS (estimated by low-frequency gain, from carotid distension rate and heart rate) and mBRS (carotid stiffness) were measured by high-precision carotid echo-tracking. PA was self-reported using the validated Baecke questionnaire. The associations between PA and nBRS and mBRS were quantified using multivariate linear regression analysis, separately in the working and nonworking population. In working adults (n=5039), occupational PA was associated with worse nBRS (unstandardized beta=-0.02; [95% CI, -0.04 to -0.003]; P=0.022) whereas sport PA was associated with better nBRS (beta=0.04; [95% CI, 0.02-0.07]; P=0.003) and mBRS (beta=-0.05; [95% CI, -0.09 to -0.00001]; P=0.049). Neither leisure PA nor total PA was associated with nBRS or mBRS. In nonworking adults (n=3610), sport PA and total PA were associated with better mBRS (beta=-0.08; [95% CI, -0.15 to 0.02]; P=0.012 and beta=-0.05; [95% CI, -0.10 to 0.009]; P=0.018) but not nBRS. These findings suggest differential associations between domains of PA and BRS and may provide insights into the mechanisms underlying the association between occupational PA and cardiovascular disease.

Original languageEnglish
Pages (from-to)1476-1483
Number of pages8
JournalHypertension
Volume74
Issue number6
DOIs
Publication statusPublished - Dec 2019

Keywords

  • association
  • blood pressure
  • cardiovascular disease
  • exercise
  • hypertension
  • HEART-RATE-VARIABILITY
  • ALL-CAUSE MORTALITY
  • CARDIOVASCULAR MORTALITY
  • MYOCARDIAL-INFARCTION
  • ARTERIAL STIFFNESS
  • BLOOD-PRESSURE
  • DISEASE RISK
  • EXERCISE
  • OLDER
  • WORK

Cite this