Association between Dietary Fibre Intake and Colorectal Adenoma: A Systematic Review and Meta-Analysis

Daniele Nucci, Cristina Fatigoni, Tania Salvatori, Mariateresa Nardi, Stefano Realdon, Vincenza Gianfredi*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Citations (Web of Science)

Abstract

PubMed/Medline, Excerpta Medica dataBASE (EMBASE) and Scopus were searched in January 2021 in order to retrieve evidence assessing the association between dietary fibre intake and the risk of colorectal adenoma in adults. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used for the reporting of results. Only primary observational studies were included. Publication bias was estimated through the Egger's test and the visual inspection of the funnel plot. Heterogeneity between studies was calculated with I-2 statistics. The search strategy identified 683 papers, 21 of which were included in our meta-analysis. Having evaluated a total of 157,725 subjects, the results suggest a protective effect of dietary fibre intake against colorectal adenoma. Effect Size (ES) was [0.71 (95% CI = 0.68-0.75), p = 0.000)]. Moderate statistical heterogeneity (Chi(2) = 61.68, df = 23, I-2 = 62.71%, p = 0.000) was found. Findings show a statistically significant (p = 0.000) and robust association between a higher intake of dietary fibre and a lower risk of colorectal adenoma, considering both the prevalent and incident risk. Moreover, the meta-regression analysis showed a borderline significant negative linear correlation between the amount of dietary fibre intake and colorectal adenoma. Lastly, we performed a subgroup analysis by sex, showing a higher protective effect for men.

Original languageEnglish
Article number4168
Number of pages23
JournalInternational Journal of Environmental Research and Public Health
Volume18
Issue number8
DOIs
Publication statusPublished - Apr 2021

Keywords

  • BIAS
  • RISK
  • adenoma
  • colorectal
  • diet
  • fibre
  • systematic review
  • FRUITS
  • SULFORAPHANE
  • INCIDENT
  • CANCER
  • POLYPS
  • PUBLICATION BIAS
  • CONSUMPTION
  • TOOL

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