Association between COMT Val158Met genotype and EEG alpha peak frequency tested in two independent cohorts

Cornelis P. M. Veth*, Martijn Arns, Wilhelmus Drinkenburg, Willem Talloen, Pieter J. Peeters, Evian Gordon, Jan K. Buitelaar

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Web of Science)

Abstract

This study could not confirm the association between the Catechol-O-Methyltransferase Val158Met polymorphism (COMT) and electroencephalographic (EEG) alpha peak frequency (APF) in two independent cohorts of 187 (96 depressed and 91 healthy participants) and 413 healthy participants. If COMT and APF play a role in depression or antidepressant treatment response, they do not have a shared pathway. We emphasize the importance of publishing null-findings for obtaining more accurate overall estimates of genetic effects. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)221-224
Number of pages4
JournalPsychiatry Research
Volume219
Issue number1
DOIs
Publication statusPublished - 30 Sep 2014
Externally publishedYes

Keywords

  • Catechol-O-Methyltransferase Val158Met polymorphism
  • Electroencephalographic alpha peak frequency
  • Major depressive disorder
  • O-METHYLTRANSFERASE COMT
  • TEST-RETEST RELIABILITY
  • PHARMACOGENETICS
  • DEPRESSION
  • POLYMORPHISM
  • VALIDATION
  • MECHANISMS
  • PHENOTYPES
  • ANXIETY
  • POWER

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