Association between cardiovascular risk factors and intracranial hemorrhage in patients with acute leukemia

Loes L Cornelissen; Aukje L Kreuger; Camila Caram-Deelder; Menno V Huisman; Rutger A Middelburg; Jean Louis H Kerkhoffs; Peter A von dem Borne; Erik A M Beckers; Karen M K de Vooght; Jürgen Kuball; Johanna G van der Bom; Jaap Jan Zwaginga

doi:10.1111/ejh.13737

Association between cardiovascular risk factors and intracranial hemorrhage in patients with acute leukemia

Loes L Cornelissen, Aukje L Kreuger, Camila Caram-Deelder, Menno V Huisman, Rutger A Middelburg, Jean Louis H Kerkhoffs, Peter A von dem Borne, Erik A M Beckers, Karen M K de Vooght, Jürgen Kuball, Johanna G van der Bom, Jaap Jan Zwaginga^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Intracranial hemorrhage is seen more frequently in acute leukemia patients compared to the general population. Besides leukemia-related risk factors, also risk factors that are present in the general population might contribute to hemorrhagic complications in leukemia patients. Of those, cardiovascular risk factors leading to chronic vascular damage could modulate the occurrence of intracranial hemorrhage in these patients, as during their disease and treatment acute endothelial damage occurs due to factors like thrombocytopenia and inflammation.

OBJECTIVES: Our aim was to explore if cardiovascular risk factors can predict intracranial hemorrhage in acute leukemia patients.

METHODS: In a case-control study nested in a cohort of acute leukemia patients, including 17 cases with intracranial hemorrhage and 55 matched control patients without intracranial hemorrhage, data on cardiovascular risk factors were collected for all patients. Analyses were performed via conditional logistic regression.

RESULTS: Pre-existing hypertension and ischemic heart disease in the medical history were associated with intracranial hemorrhage, with an incidence rate ratio of 12.9 (95% confidence interval [CI] 1.5 to 109.2) and 12.1 (95% CI 1.3 to110.7), respectively.

CONCLUSION: Both pre-existing hypertension and ischemic heart disease seem to be strong predictors of an increased risk for intracranial hemorrhage in leukemia patients.

Original language	English
Pages (from-to)	310-318
Number of pages	9
Journal	European Journal of Haematology
Volume	108
Issue number	4
Early online date	19 Dec 2021
DOIs	https://doi.org/10.1111/ejh.13737
Publication status	Published - Apr 2022

Keywords

COMPLICATIONS
HYPERTENSION
INTRACEREBRAL HEMORRHAGE
MORTALITY
POPULATION
PREDICTION
THROMBOCYTOPENIA
cardiovascular risk factors
intracranial hemorrhage
leukemia

Access to Document

10.1111/ejh.13737

Cite this

Cornelissen, L. L., Kreuger, A. L., Caram-Deelder, C., Huisman, M. V., Middelburg, R. A., Kerkhoffs, J. L. H., von dem Borne, P. A., Beckers, E. A. M., de Vooght, K. M. K., Kuball, J., van der Bom, J. G., & Zwaginga, J. J. (2022). Association between cardiovascular risk factors and intracranial hemorrhage in patients with acute leukemia. European Journal of Haematology, 108(4), 310-318. https://doi.org/10.1111/ejh.13737

@article{81b632288c4d464ab15d6b8b98c6b654,

title = "Association between cardiovascular risk factors and intracranial hemorrhage in patients with acute leukemia",

abstract = "BACKGROUND: Intracranial hemorrhage is seen more frequently in acute leukemia patients compared to the general population. Besides leukemia-related risk factors, also risk factors that are present in the general population might contribute to hemorrhagic complications in leukemia patients. Of those, cardiovascular risk factors leading to chronic vascular damage could modulate the occurrence of intracranial hemorrhage in these patients, as during their disease and treatment acute endothelial damage occurs due to factors like thrombocytopenia and inflammation.OBJECTIVES: Our aim was to explore if cardiovascular risk factors can predict intracranial hemorrhage in acute leukemia patients.METHODS: In a case-control study nested in a cohort of acute leukemia patients, including 17 cases with intracranial hemorrhage and 55 matched control patients without intracranial hemorrhage, data on cardiovascular risk factors were collected for all patients. Analyses were performed via conditional logistic regression.RESULTS: Pre-existing hypertension and ischemic heart disease in the medical history were associated with intracranial hemorrhage, with an incidence rate ratio of 12.9 (95% confidence interval [CI] 1.5 to 109.2) and 12.1 (95% CI 1.3 to110.7), respectively.CONCLUSION: Both pre-existing hypertension and ischemic heart disease seem to be strong predictors of an increased risk for intracranial hemorrhage in leukemia patients.",

keywords = "COMPLICATIONS, HYPERTENSION, INTRACEREBRAL HEMORRHAGE, MORTALITY, POPULATION, PREDICTION, THROMBOCYTOPENIA, cardiovascular risk factors, intracranial hemorrhage, leukemia",

author = "Cornelissen, {Loes L} and Kreuger, {Aukje L} and Camila Caram-Deelder and Huisman, {Menno V} and Middelburg, {Rutger A} and Kerkhoffs, {Jean Louis H} and {von dem Borne}, {Peter A} and Beckers, {Erik A M} and {de Vooght}, {Karen M K} and J{\"u}rgen Kuball and {van der Bom}, {Johanna G} and Zwaginga, {Jaap Jan}",

note = "{\textcopyright} 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",

year = "2022",

month = apr,

doi = "10.1111/ejh.13737",

language = "English",

volume = "108",

pages = "310--318",

journal = "European Journal of Haematology",

issn = "0902-4441",

publisher = "Wiley",

number = "4",

}

Cornelissen, LL, Kreuger, AL, Caram-Deelder, C, Huisman, MV, Middelburg, RA, Kerkhoffs, JLH, von dem Borne, PA, Beckers, EAM, de Vooght, KMK, Kuball, J, van der Bom, JG & Zwaginga, JJ 2022, 'Association between cardiovascular risk factors and intracranial hemorrhage in patients with acute leukemia', European Journal of Haematology, vol. 108, no. 4, pp. 310-318. https://doi.org/10.1111/ejh.13737

TY - JOUR

T1 - Association between cardiovascular risk factors and intracranial hemorrhage in patients with acute leukemia

AU - Cornelissen, Loes L

AU - Kreuger, Aukje L

AU - Caram-Deelder, Camila

AU - Huisman, Menno V

AU - Middelburg, Rutger A

AU - Kerkhoffs, Jean Louis H

AU - von dem Borne, Peter A

AU - Beckers, Erik A M

AU - de Vooght, Karen M K

AU - Kuball, Jürgen

AU - van der Bom, Johanna G

AU - Zwaginga, Jaap Jan

PY - 2022/4

Y1 - 2022/4

N2 - BACKGROUND: Intracranial hemorrhage is seen more frequently in acute leukemia patients compared to the general population. Besides leukemia-related risk factors, also risk factors that are present in the general population might contribute to hemorrhagic complications in leukemia patients. Of those, cardiovascular risk factors leading to chronic vascular damage could modulate the occurrence of intracranial hemorrhage in these patients, as during their disease and treatment acute endothelial damage occurs due to factors like thrombocytopenia and inflammation.OBJECTIVES: Our aim was to explore if cardiovascular risk factors can predict intracranial hemorrhage in acute leukemia patients.METHODS: In a case-control study nested in a cohort of acute leukemia patients, including 17 cases with intracranial hemorrhage and 55 matched control patients without intracranial hemorrhage, data on cardiovascular risk factors were collected for all patients. Analyses were performed via conditional logistic regression.RESULTS: Pre-existing hypertension and ischemic heart disease in the medical history were associated with intracranial hemorrhage, with an incidence rate ratio of 12.9 (95% confidence interval [CI] 1.5 to 109.2) and 12.1 (95% CI 1.3 to110.7), respectively.CONCLUSION: Both pre-existing hypertension and ischemic heart disease seem to be strong predictors of an increased risk for intracranial hemorrhage in leukemia patients.

AB - BACKGROUND: Intracranial hemorrhage is seen more frequently in acute leukemia patients compared to the general population. Besides leukemia-related risk factors, also risk factors that are present in the general population might contribute to hemorrhagic complications in leukemia patients. Of those, cardiovascular risk factors leading to chronic vascular damage could modulate the occurrence of intracranial hemorrhage in these patients, as during their disease and treatment acute endothelial damage occurs due to factors like thrombocytopenia and inflammation.OBJECTIVES: Our aim was to explore if cardiovascular risk factors can predict intracranial hemorrhage in acute leukemia patients.METHODS: In a case-control study nested in a cohort of acute leukemia patients, including 17 cases with intracranial hemorrhage and 55 matched control patients without intracranial hemorrhage, data on cardiovascular risk factors were collected for all patients. Analyses were performed via conditional logistic regression.RESULTS: Pre-existing hypertension and ischemic heart disease in the medical history were associated with intracranial hemorrhage, with an incidence rate ratio of 12.9 (95% confidence interval [CI] 1.5 to 109.2) and 12.1 (95% CI 1.3 to110.7), respectively.CONCLUSION: Both pre-existing hypertension and ischemic heart disease seem to be strong predictors of an increased risk for intracranial hemorrhage in leukemia patients.

KW - COMPLICATIONS

KW - HYPERTENSION

KW - INTRACEREBRAL HEMORRHAGE

KW - MORTALITY

KW - POPULATION

KW - PREDICTION

KW - THROMBOCYTOPENIA

KW - cardiovascular risk factors

KW - intracranial hemorrhage

KW - leukemia

U2 - 10.1111/ejh.13737

DO - 10.1111/ejh.13737

M3 - Article

C2 - 34923665

SN - 0902-4441

VL - 108

SP - 310

EP - 318

JO - European Journal of Haematology

JF - European Journal of Haematology

IS - 4

ER -