TY - JOUR
T1 - Association between arterial stiffness, cerebral small vessel disease and cognitive impairment: A systematic review and meta-analysis
AU - van Sloten, Thomas T.
AU - Protogerou, Athanase D.
AU - Henry, Ronald M. A.
AU - Schram, Miranda T.
AU - Launer, Lenore J.
AU - Stehouwer, Coen D. A.
PY - 2015/6
Y1 - 2015/6
N2 - Arterial stiffness may be a cause of cerebral small vessel disease and cognitive impairment. We therefore performed a systematic review and meta-analysis of studies on the association between stiffness, cerebral small vessel disease and cognitive impairment. For the associations between stiffness (i.e. carotid-femoral pulse wave velocity (cfPWV), brachial-ankle PVVV (baPWV), carotid stiffness and pulse pressure) on the one hand and cerebral small vessel disease and cognitive impairment on the other, we identified 23 (n = 15,666/20 cross-sectional; 1 longitudinal; 2 combined cross-sectional/longitudinal) and 41 studies (n= 57,671/26 cross-sectional; 11 longitudinal; 4 combined cross-sectional/longitudinal), respectively. Pooled analyses of cross-sectional studies showed that greater stiffness was associated with markers of cerebral small vessel disease with odds ratios, per +1 SD, of 1.29-1.32 (P
AB - Arterial stiffness may be a cause of cerebral small vessel disease and cognitive impairment. We therefore performed a systematic review and meta-analysis of studies on the association between stiffness, cerebral small vessel disease and cognitive impairment. For the associations between stiffness (i.e. carotid-femoral pulse wave velocity (cfPWV), brachial-ankle PVVV (baPWV), carotid stiffness and pulse pressure) on the one hand and cerebral small vessel disease and cognitive impairment on the other, we identified 23 (n = 15,666/20 cross-sectional; 1 longitudinal; 2 combined cross-sectional/longitudinal) and 41 studies (n= 57,671/26 cross-sectional; 11 longitudinal; 4 combined cross-sectional/longitudinal), respectively. Pooled analyses of cross-sectional studies showed that greater stiffness was associated with markers of cerebral small vessel disease with odds ratios, per +1 SD, of 1.29-1.32 (P
KW - Arterial stiffness
KW - Cerebral small vessel disease
KW - White matter hyperintensities
KW - Cerebral microbleeds
KW - Cerebral infarcts
KW - Cognitive impairment
KW - Dementia
KW - Meta-analysis
KW - Systematic review
U2 - 10.1016/j.neubiorev.2015.03.011
DO - 10.1016/j.neubiorev.2015.03.011
M3 - Article
C2 - 25827412
SN - 0149-7634
VL - 53
SP - 121
EP - 130
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
ER -