TY - JOUR
T1 - Association between apolipoprotein E4 and cognitive decline in elderly adults
AU - Packard, C.J.
AU - Westendorp, R.G.J.
AU - Stott, D.J.
AU - Caslake, M.J.
AU - Murray, H.M.
AU - Sheperd, J.
AU - Blauw, G.J.
AU - Murphy, M.B.
AU - Bollen, E.L.
AU - Buckley, B.M.
AU - Cobbe, S.
AU - Ford, I.
AU - Gaw, A.
AU - Hyland, M.
AU - Jukema, J.W.
AU - Kamper, A.M.
AU - Macfarlane, P W.
AU - Jolles, J.
AU - Perry, IJ.
AU - Sweeney, B.J.
AU - Twomey, C.
PY - 2007/1/1
Y1 - 2007/1/1
N2 - OBJECTIVE: To determine the influence of apolipoprotein E on cognitive decline in a cohort of elderly men and women. DESIGN: Prospective study. SETTING: Scotland, Ireland, and the Netherlands. PARTICIPANTS: Five thousand eight hundred four subjects aged 70 to 82 from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). MEASUREMENTS: Subjects were assessed at baseline and over a mean 3.2-year (range 0.7-4.2) follow-up for memory (Picture-Word Recall), speed of information processing (Stroop and Letter-Digit Coding), global cognitive function (Mini-Mental State Examination), and activities of daily living. RESULTS: At baseline, subjects with apolipoprotein E-4 versus those without E-4 had poorer memory performance (mean score difference -0.20 (95% confidence interval (CI)=-0.31 to -0.09) for immediate recall and -0.32 (95% CI=-0.48 to -0.16) for delayed recall and slower information processing (difference in Stroop, 2.79 seconds, (95% CI=1.20-4.28); Letter-Digit score, -0.36, (95% CI=-0.77-0.05). Subjects with apolipoprotein E-4 showed a greater decline in immediate (-0.22, 95% CI=-0.33 to -0.11) and delayed (-0.30, 95% CI=-0.46 to -0.15) memory scores but no significant change in speed of information processing (Stroop, P=.17; Letter-Digit, P=.06). Memory scores decreased 2.5% from baseline in those without E-4, 4.3% in E-4 heterozygotes (P=.01 for immediate and P=.03 for delayed, vs no E-4) and 8.9% to 13.8% in E-4 homozygotes (P=.04 for immediate and P=.004 for delayed, vs heterozygotes). Apolipoprotein E-4 was associated with greater decline in instrumental activities of daily living (P
AB - OBJECTIVE: To determine the influence of apolipoprotein E on cognitive decline in a cohort of elderly men and women. DESIGN: Prospective study. SETTING: Scotland, Ireland, and the Netherlands. PARTICIPANTS: Five thousand eight hundred four subjects aged 70 to 82 from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). MEASUREMENTS: Subjects were assessed at baseline and over a mean 3.2-year (range 0.7-4.2) follow-up for memory (Picture-Word Recall), speed of information processing (Stroop and Letter-Digit Coding), global cognitive function (Mini-Mental State Examination), and activities of daily living. RESULTS: At baseline, subjects with apolipoprotein E-4 versus those without E-4 had poorer memory performance (mean score difference -0.20 (95% confidence interval (CI)=-0.31 to -0.09) for immediate recall and -0.32 (95% CI=-0.48 to -0.16) for delayed recall and slower information processing (difference in Stroop, 2.79 seconds, (95% CI=1.20-4.28); Letter-Digit score, -0.36, (95% CI=-0.77-0.05). Subjects with apolipoprotein E-4 showed a greater decline in immediate (-0.22, 95% CI=-0.33 to -0.11) and delayed (-0.30, 95% CI=-0.46 to -0.15) memory scores but no significant change in speed of information processing (Stroop, P=.17; Letter-Digit, P=.06). Memory scores decreased 2.5% from baseline in those without E-4, 4.3% in E-4 heterozygotes (P=.01 for immediate and P=.03 for delayed, vs no E-4) and 8.9% to 13.8% in E-4 homozygotes (P=.04 for immediate and P=.004 for delayed, vs heterozygotes). Apolipoprotein E-4 was associated with greater decline in instrumental activities of daily living (P
U2 - 10.1111/j.1532-5415.2007.01415.x
DO - 10.1111/j.1532-5415.2007.01415.x
M3 - Article
C2 - 17979899
SN - 1064-7481
VL - 55
SP - 1777
EP - 1785
JO - American Journal of Geriatric Psychiatry
JF - American Journal of Geriatric Psychiatry
IS - 11
ER -