Abstract
Background To translate and linguistically validate the Assessment of Quality of Life 8-dimensions (AQoL-8D) for use in the Netherlands and to compare the psychometric properties of AQoL-8D with the EuroQol 5-dimensions 5-levels (EQ-5D-5L) in two patient samples. Methods AQoL-8D was translated from English into Dutch. The translated AQoL-8D was then administered alongside the EQ-5D-5L at baseline and follow-up of two Dutch randomized controlled trials among patients with epilepsy and schizophrenia. These data were subjected to a post-hoc analysis assessing the psychometric properties of AQol-8D vis-a-vis EQ-5D-5L in terms of known-groups construct validity, responsiveness, and floor/ceiling effects. Results In total, 103 epilepsy patients and 99 schizophrenia patients were included in this study. In both datasets, the two instruments discriminated between known-groups, but in schizophrenia, AQoL-8D showed higher responsiveness than EQ-5D-5L, while both instruments showed equal responsiveness in epilepsy. Ceiling effects were only found for EQ-5D-5L in both epilepsy (26.6%) and schizophrenia (6.1%). Conclusion Our results have shown that, among other things, AQoL-8D presents better ability to discriminate between known-groups and shows no ceiling effect. Based on our results, we would recommend the use of AQoL-8D in addition to EQ-5D-5L in trials assessing patient's quality of life in patients with epilepsy or schizophrenia.
Original language | English |
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Pages (from-to) | 795-803 |
Number of pages | 9 |
Journal | Expert Review of Pharmacoeconomics & Outcomes Research |
Volume | 22 |
Issue number | 5 |
Early online date | 1 Sept 2021 |
DOIs | |
Publication status | Published - 4 Jul 2022 |
Keywords
- Validity
- EuroQoL-5D
- AQoL-8D
- responsiveness
- quality of life
- utility
- PREFERENCE-BASED MEASURES
- MENTAL-HEALTH
- EQ-5D
- UTILITY
- SF-6D
- INSTRUMENTS
- RESPONSIVENESS
- QUESTIONNAIRE
- VALIDITY
- TARIFF