Assessment of left ventricular mechanical dyssynchrony in left bundle branch block canine model: Comparison between cine and tagged MRI

Salvatore Saporito*, Hans C. van Assen, Patrick Houthuizen, Jean-Paul M. M. Aben, Marc Strik, Lars B. van Middendorp, Frits W. Prinzen, Massimo Mischi

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Purpose To compare cine and tagged magnetic resonance imaging (MRI) for left ventricular dyssynchrony assessment in left bundle branch block (LBBB), using the time-to-peak contraction timing, and a novel approach based on cross-correlation. Materials and MethodsWe evaluated a canine model dataset (n=10) before (pre-LBBB) and after induction of isolated LBBB (post-LBBB). Multislice short-axis tagged and cine MRI images were acquired using a 1.5 T scanner. We computed contraction time maps by cross-correlation, based on the timing of radial wall motion and of circumferential strain. Finally, we estimated dyssynchrony as the standard deviation of the contraction time over the different regions of the myocardium. ResultsInduction of LBBB resulted in a significant increase in dyssynchrony (cine: 13.03.9 msec for pre-LBBB, and 26.4 +/- 5.0 msec for post-LBBB, P=0.005; tagged: 17.1 +/- 5.0 msec at for pre-LBBB, and 27.9 +/- 9.8 msec for post-LBBB, P=0.007). Dyssynchrony assessed by cine and tagged MRI were in agreement (r=0.73, P=0.0003); differences were in the order of time difference between successive frames of 20 msec (bias: -2.9 msec; limit of agreement: 10.1 msec). Contraction time maps were derived; agreement was found in the contraction patterns derived from cine and tagged MRI (mean difference in contraction time per segment: 3.6 +/- 13.7 msec). ConclusionThis study shows that the proposed method is able to quantify dyssynchrony after induced LBBB in an animal model. Cine-assessed dyssynchrony agreed with tagged-derived dyssynchrony, in terms of magnitude and spatial direction. J. MAGN. RESON. IMAGING 2016;44:956-963.
Original languageEnglish
Pages (from-to)956-963
JournalJournal of Magnetic Resonance Imaging
Issue number4
Publication statusPublished - Oct 2016


  • magnetic resonance imaging
  • dyssynchrony
  • left ventricle
  • left bundle branch block

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