TY - JOUR
T1 - Artificial intelligence for detecting keratoconus
AU - Vandevenne, Magali
AU - Favuzza, Eleonora
AU - Veta, Mitko
AU - Lucenteforte, E.
AU - Berendschot, Tos
AU - Mencucci, Rita
AU - Nuijts, Rudy
AU - Virgil, Gianni
AU - Dickman, Mor M.
N1 - Funding Information:
This protocol was supported by the HSC Research and Development (R&D) Division of the Public Health Agency which funds the Cochrane Eyes and Vision editorial base at Queen's University Belfast.
Publisher Copyright:
Copyright © 2021 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
PY - 2021/12/17
Y1 - 2021/12/17
N2 - Objectives: This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows:. The primary objective is to assess the diagnostic accuracy of AI algorithms in the detection of keratoconus in patients presenting with refractive errors, especially those whose vision can no longer be corrected fully with glasses, patients seeking corneal refractive surgery or those suspected of having keratoconus. AI could help ophthalmologists, optometrists and other eye-care professionals to make decisions on referral to cornea specialists for these patients. Secondary objectives To compare different AI algorithms, e.g. neural networks, decision trees, support vector machines. To assess potential causes of heterogeneity in diagnostic performance across studies, according to the following: index test methodology: pre-processing techniques, core AI method and postprocessing techniques; sources of input to train algorithms: topography and tomography images from Placido-disc system or Scheimpflug system or slit-scanning system or OCT, number of training and testing cases/images, label/endpoint variable used for training; study setting; study design, retrospective or prospective studies; ethnicity, or geographic area as its proxy; different index test positivity criteria provided by topography or tomography device; reference standard used, topography or tomography, one or two cornea-specialists; definition of keratoconus used; mean age; patient recruitment; severity of keratoconus: clinically manifest keratoconus subclinical keratoconus.
AB - Objectives: This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows:. The primary objective is to assess the diagnostic accuracy of AI algorithms in the detection of keratoconus in patients presenting with refractive errors, especially those whose vision can no longer be corrected fully with glasses, patients seeking corneal refractive surgery or those suspected of having keratoconus. AI could help ophthalmologists, optometrists and other eye-care professionals to make decisions on referral to cornea specialists for these patients. Secondary objectives To compare different AI algorithms, e.g. neural networks, decision trees, support vector machines. To assess potential causes of heterogeneity in diagnostic performance across studies, according to the following: index test methodology: pre-processing techniques, core AI method and postprocessing techniques; sources of input to train algorithms: topography and tomography images from Placido-disc system or Scheimpflug system or slit-scanning system or OCT, number of training and testing cases/images, label/endpoint variable used for training; study setting; study design, retrospective or prospective studies; ethnicity, or geographic area as its proxy; different index test positivity criteria provided by topography or tomography device; reference standard used, topography or tomography, one or two cornea-specialists; definition of keratoconus used; mean age; patient recruitment; severity of keratoconus: clinically manifest keratoconus subclinical keratoconus.
KW - DIABETIC-RETINOPATHY
KW - COLLAGEN ORIENTATION
KW - PROGRESSION
KW - VALIDATION
KW - DIAGNOSIS
U2 - 10.1002/14651858.cd014911
DO - 10.1002/14651858.cd014911
M3 - Article
SN - 1469-493X
VL - 2021
JO - Cochrane Database of Systematic Reviews
JF - Cochrane Database of Systematic Reviews
IS - 12
M1 - CD014911
ER -