@article{3120c9e71bc949a692fd98d8a344f110,
title = "Artificial intelligence-driven phenotyping of zebrafish psychoactive drug responses",
abstract = "Zebrafish (Danio rerio) are rapidly emerging in biomedicine as promising tools for disease modelling and drug discovery. The use of zebrafish for neuroscience research is also growing rapidly, necessitating novel reliable and unbiased methods of neurophenotypic data collection and analyses. Here, we applied the artificial intelligence (AI) neural network-based algorithms to a large dataset of adult zebrafish locomotor tracks collected previously in a series of in vivo experiments with multiple established psychotropic drugs. We first trained AI to recognize various drugs from a wide range of psychotropic agents tested, and then confirmed prediction accuracy of trained AI by comparing several agents with known similar behavioral and pharmacological profiles. Presenting a framework for innovative neurophenotyping, this proof-of-concept study aims to improve AI-driven movement pattern classification in zebrafish, thereby fostering drug discovery and development utilizing this key model organism.",
keywords = "ADULT ZEBRAFISH, ANXIETY, Artificial intelligence, BEHAVIOR, CANCER, CNS drug screening, DEEP, FRAMEWORK, LSD, Locomotion, MODEL, NEURAL-NETWORKS, Neural network, TOOLS, Zebrafish, SYSTEM",
author = "D.V. Bozhko and V.O. Myrov and S.M. Kolchanova and A.I. Polovian and G.K. Galumov and K.A. Demin and K.N. Zabegalov and T. Strekalova and {De Abreu}, M.S. and E.V. Petersen and A.V. Kalueff",
note = "Funding Information: DVB, VOM, SMK, AIP and GKG are affiliated with a contract research organization (CRO), ZebraML, Inc. (Houston, TX, USA). AVK has been affiliated, as a founder, with a CRO, ZENEREI, LLC (New Orleans, LA, USA). Both CROs are involved in developing innovative methods of animal neurophenotyping, including zebrafish-based drug screens. AVK research is supported by the Southwest University (Chongqing, China). KD research is supported by St. Petersburg State University (SPSU) Rector's Fellowship and State Budgetary Funds to SPSU (project 51130521). KNZ and the research team are also supported by State Budgetary Funds to Granov Russian Research Center of Radiology and Surgical Technologies. Funding Information: DVB, VOM, SMK, AIP and GKG are affiliated with a contract research organization (CRO), ZebraML, Inc. (Houston, TX, USA). AVK has been affiliated, as a founder, with a CRO, ZENEREI, LLC (New Orleans, LA, USA). Both CROs are involved in developing innovative methods of animal neurophenotyping, including zebrafish-based drug screens. AVK research is supported by the Southwest University (Chongqing, China). KD research is supported by St. Petersburg State University (SPSU) Rector's Fellowship and State Budgetary Funds to SPSU (project 51130521 ). KNZ and the research team are also supported by State Budgetary Funds to Granov Russian Research Center of Radiology and Surgical Technologies. Publisher Copyright: {\textcopyright} 2021",
year = "2022",
month = jan,
day = "10",
doi = "10.1016/j.pnpbp.2021.110405",
language = "English",
volume = "112",
journal = "Progress in Neuro-Psychopharmacology & Biological Psychiatry",
issn = "0278-5846",
publisher = "Elsevier Science",
}