Arterial stiffness and hypertension in a large population of untreated individuals: the Rotterdam Study

Germaine C. Verwoert*, Oscar H. Franco, Arnold P. G. Hoeks, Robert S. Reneman, Albert Hofman, Cornelia M. V. Duijn, Eric J. G. Sijbrands, Jacqueline C. M. Witteman, Francesco U. S. Mattace-Raso

*Corresponding author for this work

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Objective: We studied whether arterial stiffness measured as aortic pulse wave velocity (aPWV) and carotid distensibility was associated with different subtypes of hypertension in a large population of untreated middle-aged and elderly men and women. Methods: The study was conducted within the framework of the population-based Rotterdam Study. We included 4088 individuals with information on aPWV, with 3554 individuals with carotid distensibility measurements without use of antihypertensive medication. Isolated systolic hypertension (ISH) was defined as SBP at least 140mmHg and DBP less than 90 mmHg. Combined systolic and diastolic hypertension (Sys/Dia hypertension) was defined as SBP at least 140mmHg and DBP at least 90 mmHg. Analysis of covariance was used to compare means of arterial stiffness for the different subtypes of hypertension. Multinomial logistic regression analysis was performed to investigate the association of arterial stiffness and the subtypes of hypertension in models adjusted for age, sex, mean arterial pressure, heart rate and cardiovascular risk factors. Results: The mean age of the individuals was 68 years: 45.3% were men, 1597 individuals had ISH and 441 individuals had Sys/Dia hypertension. aPWV was higher (13.2 vs. 12.9 m/s; P=0.008) in individuals with ISH compared to those with Sys/Dia hypertension. Multivariate odds ratios and corresponding 95% confidence interval of aPWV for ISH were 1.53 (1.38-1.71) and 1.28 (1.09-1.53) for Sys/Dia hypertension. Corresponding odds ratios associated with carotid distensibility were 0.84 (0.75-0.94) and 0.66 (0.54-0.81), respectively. Age significantly modified the association of aPWV with subtypes of hypertension (P
Original languageEnglish
Pages (from-to)1606-1612
JournalJournal of Hypertension
Issue number8
Publication statusPublished - Aug 2014


  • ageing
  • arterial stiffness
  • combined systolic and diastolic hypertension
  • isolated systolic hypertension
  • population-based study

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