Arginase-1 mRNA expression correlates with myeloid-derived suppressor cell levels in peripheral blood of NSCLC patients

Marlies E. Heuvers; Femke Muskens; Koen Bezemer; Margaretha Lambers; Anne-Marie C. Dingemans; Harry J. M. Groen; Egbert F. Smit; Henk C. Hoogsteden; Joost P. J. J. Hegmans; Joachim G. J. V. Aerts

doi:10.1016/j.lungcan.2013.06.005

Arginase-1 mRNA expression correlates with myeloid-derived suppressor cell levels in peripheral blood of NSCLC patients

Marlies E. Heuvers^*, Femke Muskens, Koen Bezemer, Margaretha Lambers, Anne-Marie C. Dingemans, Harry J. M. Groen, Egbert F. Smit, Henk C. Hoogsteden, Joost P. J. J. Hegmans, Joachim G. J. V. Aerts

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature and progenitor myeloid cells with immunosuppressive activity that are increased in cancer patients. Until now, the characterization of MDSC in humans was very challenging. The aim of this study was to determine the characterization and optimal assessment of MDSC and to investigate their presence and function in blood of advanced-stage NSCLC patients. We determined MDSC and lymphocyte populations in peripheral blood mononuclear cells (PBMC) samples of 185 treatment-naive NSCLC patients and 20 healthy controls (HC). NSCLC patients had an increased population of PMN-MDSC compared to HC (p

Original language	English
Pages (from-to)	468-474
Journal	Lung Cancer
Volume	81
Issue number	3
DOIs	https://doi.org/10.1016/j.lungcan.2013.06.005
Publication status	Published - Sept 2013

Keywords

NSCLC
Myeloid-derived suppressor cells
Arginase-1
Immuno-oncology

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10.1016/j.lungcan.2013.06.005

Cite this

Heuvers, M. E., Muskens, F., Bezemer, K., Lambers, M., Dingemans, A.-M. C., Groen, H. J. M., Smit, E. F., Hoogsteden, H. C., Hegmans, J. P. J. J., & Aerts, J. G. J. V. (2013). Arginase-1 mRNA expression correlates with myeloid-derived suppressor cell levels in peripheral blood of NSCLC patients. Lung Cancer, 81(3), 468-474. https://doi.org/10.1016/j.lungcan.2013.06.005

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abstract = "Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature and progenitor myeloid cells with immunosuppressive activity that are increased in cancer patients. Until now, the characterization of MDSC in humans was very challenging. The aim of this study was to determine the characterization and optimal assessment of MDSC and to investigate their presence and function in blood of advanced-stage NSCLC patients. We determined MDSC and lymphocyte populations in peripheral blood mononuclear cells (PBMC) samples of 185 treatment-naive NSCLC patients and 20 healthy controls (HC). NSCLC patients had an increased population of PMN-MDSC compared to HC (p",

keywords = "NSCLC, Myeloid-derived suppressor cells, Arginase-1, Immuno-oncology",

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AU - Heuvers, Marlies E.

AU - Muskens, Femke

AU - Bezemer, Koen

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AU - Dingemans, Anne-Marie C.

AU - Groen, Harry J. M.

AU - Smit, Egbert F.

AU - Hoogsteden, Henk C.

AU - Hegmans, Joost P. J. J.

AU - Aerts, Joachim G. J. V.

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