Are there consistent abnormalities in event-related EEG oscillations in patients with Alzheimer's disease compared to other diseases belonging to dementia?

Bahar Guentekin*, Tuba Aktürk, Xianghong Arakaki, Laura Bonanni, Claudio Del Percio, Rebecca Edelmayer, Francesca Farina, Raffaele Ferri, Lutfu Hanoglu, Sanjeev Kumar, Roberta Lizio, Susanna Lopez, Brian Murphy, Giuseppe Noce, Fiona Randall, Alexander T. Sack, Fabrizio Stocchi, Gorsev Yener, Ebru Yildirim, Claudio Babiloni

*Corresponding author for this work

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Abstract

Cerebrospinal and structural-molecular neuroimaging in-vivo biomarkers are recommended for diagnostic purposes in Alzheimer's disease (AD) and other dementias; however, they do not explain the effects of AD neuropathology on neurophysiological mechanisms underpinning cognitive processes. Here, an Expert Panel from the Electrophysiology Professional Interest Area of the Alzheimer's Association reviewed the field literature and reached consensus on the event-related electroencephalographic oscillations (EROs) that show consistent abnormalities in patients with significant cognitive deficits due to Alzheimer's, Parkinson's (PD), Lewy body (LBD), and cerebrovascular diseases. Converging evidence from oddball paradigms showed that, as compared to cognitively unimpaired (CU) older adults, AD patients had lower amplitude in widespread delta (>4 Hz) and theta (4-7 Hz) phase-locked EROs as a function of disease severity. Similar effects were also observed in PD, LBD, and/or cerebrovascular cognitive impairment patients. Non-phase-locked alpha (8-12 Hz) and beta (13-30 Hz) oscillations were abnormally reduced (event-related desynchronization, ERD) in AD patients relative to CU. However, studies on patients with other dementias remain lacking. Delta and theta phase-locked EROs during oddball tasks may be useful neurophysiological biomarkers of cognitive systems at work in heuristic and intervention clinical trials performed in AD patients, but more research is needed regarding their potential role for other dementias.

Original languageEnglish
Article number13934
Number of pages42
JournalPsychophysiology
Volume59
Issue number5
Early online date30 Aug 2021
DOIs
Publication statusPublished - May 2022

Keywords

  • Alzheimer's disease mild cognitive impairment (ADMCI)
  • Alzheimer's disease (AD)
  • event-related desynchronization
  • event-related oscillations (EROs)
  • event-related potentials (ERPs)
  • event-related synchronization
  • lewy body dementia (LBD)
  • Parkinson's disease (PD)
  • vascular cognitive impairment (VCI)
  • MILD COGNITIVE IMPAIRMENT
  • GAMMA-BAND ACTIVITY
  • SHORT-TERM-MEMORY
  • TIME-FREQUENCY ANALYSIS
  • AGE-RELATED DIFFERENCES
  • FRONTAL-MIDLINE THETA
  • WORKING-MEMORY
  • BRAIN OSCILLATIONS
  • PARKINSONS-DISEASE
  • FUNCTIONAL CONNECTIVITY

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