Are Dopamine Oxidation Metabolites Involved in the Loss of Dopaminergic Neurons in the Nigrostriatal System in Parkinson's Disease?

Andrea Herrera, Patricia Munoz, Harry W. M. Steinbusch, Juan Segura-Aguilar*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

66 Citations (Web of Science)
Original languageEnglish
Pages (from-to)702-711
Number of pages10
JournalAcs Chemical Neuroscience
Volume8
Issue number4
DOIs
Publication statusPublished - Apr 2017

Keywords

  • Neurodegeneration
  • astrocytes
  • alpha-synuclein
  • mitochondria dysfunction
  • autophagy dysfunction
  • proteasome dysfunction
  • neuroinflammation
  • endoplasmic reticulum stress
  • PROTEIN-DEGRADATION PATHWAYS
  • SYNUCLEIN OLIGOMER FORMATION
  • UBIQUITIN-PROTEASOME SYSTEM
  • MITOCHONDRIAL COMPLEX I
  • NRF2 SIGNALING PATHWAY
  • ALPHA-SYNUCLEIN
  • DT-DIAPHORASE
  • SUBSTANTIA-NIGRA
  • CELL-DEATH
  • RAT-BRAIN

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