Abstract
A novel and portable extracorporeal CO2-removal device was evaluated to provide additional gas transfer, auxiliary to standard therapy in severe acute hypercapnic respiratory failure. A dual-lumen catheter was inserted percutaneously in five subjects (mean age 55+/-0.4 years) and, subsequently, connected to the CO2-removal device. The median duration on support was 45 hours (interquartile range 26-156), with a blood flow rate of approximately 500 mL/min. The mean PaCO2 decreased from 95.8+/-21.9 mmHg to 63.9+/-19.6 mmHg with the pH improving from 7.11+/-0.1 to 7.26+/-0.1 in the initial 4 hours of support. Three subjects were directly weaned from the CO2-removal device and mechanical ventilation, one subject was converted to ECMO and one subject died following withdrawal of support. No systemic bleeding or device complications were observed. Low-flow CO2 removal adjuvant to standard therapy was effective in steadily removing CO2, limiting the progression of acidosis in subjects with severe acute hypercapnic respiratory failure.
Original language | English |
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Pages (from-to) | 149-155 |
Number of pages | 7 |
Journal | Perfusion |
Volume | 31 |
Issue number | 2 |
Early online date | 3 Jun 2015 |
DOIs | |
Publication status | Published - Mar 2016 |
Keywords
- acute hypercapnic respiratory failure
- COPD
- acidosis
- extracorporeal CO2 removal
- low-flow
- EXTRACORPOREAL MEMBRANE-OXYGENATION
- CARBON-DIOXIDE REMOVAL
- NONINVASIVE VENTILATION
- CLINICAL-TRIAL
- EXACERBATIONS
- PREDICTORS
- MORTALITY
- SURVIVAL