Application of an omonasteine ligation strategy for the total chemical synthesis of the BRD7 bromodomain

Pieter Van de Vijver; Liesbeth Scheer; Judy van Beijnum; Arjan Griffioen; Tilman M. Hackeng

doi:10.1039/c2cc34956f

Application of an omonasteine ligation strategy for the total chemical synthesis of the BRD7 bromodomain

Pieter Van de Vijver^*
, Liesbeth Scheer
, Judy van Beijnum
, Arjan Griffioen
, Tilman M. Hackeng

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The use of omonasteine (Omo) in sequential peptide ligation strategies extends the scope of homocysteine (Hcy) ligation to longer, methionine-rich proteins. Hcy-to-Omo conversion can be performed on-resin, while the Omo-to-Hcy deprotection can be performed in situ after peptide ligation. This strategy was successfully applied in the synthesis of the BRD7 bromodomain.

Original language	English
Pages (from-to)	9403-9405
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	75
DOIs	https://doi.org/10.1039/c2cc34956f
Publication status	Published - 2012

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10.1039/c2cc34956f

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title = "Application of an omonasteine ligation strategy for the total chemical synthesis of the BRD7 bromodomain",

abstract = "The use of omonasteine (Omo) in sequential peptide ligation strategies extends the scope of homocysteine (Hcy) ligation to longer, methionine-rich proteins. Hcy-to-Omo conversion can be performed on-resin, while the Omo-to-Hcy deprotection can be performed in situ after peptide ligation. This strategy was successfully applied in the synthesis of the BRD7 bromodomain.",

author = "\{Van de Vijver\}, Pieter and Liesbeth Scheer and \{van Beijnum\}, Judy and Arjan Griffioen and Hackeng, \{Tilman M.\}",

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doi = "10.1039/c2cc34956f",

language = "English",

volume = "48",

pages = "9403--9405",

journal = "Chemical Communications",

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T1 - Application of an omonasteine ligation strategy for the total chemical synthesis of the BRD7 bromodomain

AU - Van de Vijver, Pieter

AU - Scheer, Liesbeth

AU - van Beijnum, Judy

AU - Griffioen, Arjan

AU - Hackeng, Tilman M.

PY - 2012

Y1 - 2012

N2 - The use of omonasteine (Omo) in sequential peptide ligation strategies extends the scope of homocysteine (Hcy) ligation to longer, methionine-rich proteins. Hcy-to-Omo conversion can be performed on-resin, while the Omo-to-Hcy deprotection can be performed in situ after peptide ligation. This strategy was successfully applied in the synthesis of the BRD7 bromodomain.

AB - The use of omonasteine (Omo) in sequential peptide ligation strategies extends the scope of homocysteine (Hcy) ligation to longer, methionine-rich proteins. Hcy-to-Omo conversion can be performed on-resin, while the Omo-to-Hcy deprotection can be performed in situ after peptide ligation. This strategy was successfully applied in the synthesis of the BRD7 bromodomain.

U2 - 10.1039/c2cc34956f

DO - 10.1039/c2cc34956f

M3 - Article

C2 - 22889936

SN - 1359-7345

VL - 48

SP - 9403

EP - 9405

JO - Chemical Communications

JF - Chemical Communications

IS - 75

ER -

Application of an omonasteine ligation strategy for the total chemical synthesis of the BRD7 bromodomain

Abstract

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