Application of adenosine 5'-triphosphate (ATP) infusions in palliative home care: design of a randomized clinical trial

S. Beijer-  van Eck; E. van Rossum; P.S.G.J. Hupperets; C. Spreeuwenberg; M. van den Beuken; R.A.G. Winkens; L. Ars; B.E. van den Borne; A. de Graeff; P.C. Dagnelie

doi:10.1186/1471-2458-7-4

Application of adenosine 5'-triphosphate (ATP) infusions in palliative home care: design of a randomized clinical trial

S. Beijer- van Eck^*, E. van Rossum, P.S.G.J. Hupperets, C. Spreeuwenberg, M. van den Beuken, R.A.G. Winkens, L. Ars, B.E. van den Borne, A. de Graeff, P.C. Dagnelie

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Palliative care in cancer aims at alleviating the suffering of patients. A previous study in patients with advanced non-small-cell lung cancer showed that adenosine 5'-triphosphate (ATP) infusions had a favourable effect on fatigue, appetite, body weight, muscle strength, functional status and quality of life. The present study was designed 1. To evaluate whether ATP has favourable effects in terminally ill cancer patients, 2. To evaluate whether ATP infusions may reduce family caregiver burden and reduce the use of professional health care services, and 3. To test the feasibility of application of ATP infusions in a home care setting. METHODS/DESIGN: The study can be characterized as an open-labelled randomized controlled trial with two parallel groups. The intervention group received usual palliative care, two visits by an experienced dietician for advice, and regular ATP infusions over a period of 8 weeks. The control group received palliative care as usual and dietetic advice, but no ATP. This paper gives a description of the study design, selection of patients, interventions and outcome measures. DISCUSSION: From April 2002 through October 2006, a total of 100 patients have been randomized. Follow-up of patients will be completed in December 2006. At the time of writing, five patients are still in follow up. Of the 95 patients who have completed the study, 69 (73%) have completed four weeks of follow-up, and 53 (56%) have completed the full eight-week study period. The first results are expected in 2007.

Original language	English
Pages (from-to)	4
Journal	BMC Public Health
Volume	7
DOIs	https://doi.org/10.1186/1471-2458-7-4
Publication status	Published - 1 Jan 2007

Access to Document

10.1186/1471-2458-7-4Licence: CC BY

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17210069

Cite this

Beijer- van Eck, S., van Rossum, E., Hupperets, P. S. G. J., Spreeuwenberg, C., van den Beuken, M., Winkens, R. A. G., Ars, L., van den Borne, B. E., de Graeff, A., & Dagnelie, P. C. (2007). Application of adenosine 5'-triphosphate (ATP) infusions in palliative home care: design of a randomized clinical trial. BMC Public Health, 7, 4. https://doi.org/10.1186/1471-2458-7-4

@article{40e78a3c41754006a5d4fc2325eacbac,

title = "Application of adenosine 5'-triphosphate (ATP) infusions in palliative home care: design of a randomized clinical trial",

abstract = "BACKGROUND: Palliative care in cancer aims at alleviating the suffering of patients. A previous study in patients with advanced non-small-cell lung cancer showed that adenosine 5'-triphosphate (ATP) infusions had a favourable effect on fatigue, appetite, body weight, muscle strength, functional status and quality of life. The present study was designed 1. To evaluate whether ATP has favourable effects in terminally ill cancer patients, 2. To evaluate whether ATP infusions may reduce family caregiver burden and reduce the use of professional health care services, and 3. To test the feasibility of application of ATP infusions in a home care setting. METHODS/DESIGN: The study can be characterized as an open-labelled randomized controlled trial with two parallel groups. The intervention group received usual palliative care, two visits by an experienced dietician for advice, and regular ATP infusions over a period of 8 weeks. The control group received palliative care as usual and dietetic advice, but no ATP. This paper gives a description of the study design, selection of patients, interventions and outcome measures. DISCUSSION: From April 2002 through October 2006, a total of 100 patients have been randomized. Follow-up of patients will be completed in December 2006. At the time of writing, five patients are still in follow up. Of the 95 patients who have completed the study, 69 (73%) have completed four weeks of follow-up, and 53 (56%) have completed the full eight-week study period. The first results are expected in 2007.",

author = "{Beijer- van Eck}, S. and {van Rossum}, E. and P.S.G.J. Hupperets and C. Spreeuwenberg and {van den Beuken}, M. and R.A.G. Winkens and L. Ars and {van den Borne}, B.E. and {de Graeff}, A. and P.C. Dagnelie",

year = "2007",

month = jan,

day = "1",

doi = "10.1186/1471-2458-7-4",

language = "English",

volume = "7",

pages = "4",

journal = "BMC Public Health",

issn = "1471-2458",

publisher = "BioMed Central Ltd",

}

TY - JOUR

T1 - Application of adenosine 5'-triphosphate (ATP) infusions in palliative home care: design of a randomized clinical trial

AU - Beijer- van Eck, S.

AU - van Rossum, E.

AU - Hupperets, P.S.G.J.

AU - Spreeuwenberg, C.

AU - van den Beuken, M.

AU - Winkens, R.A.G.

AU - Ars, L.

AU - van den Borne, B.E.

AU - de Graeff, A.

AU - Dagnelie, P.C.

PY - 2007/1/1

Y1 - 2007/1/1

N2 - BACKGROUND: Palliative care in cancer aims at alleviating the suffering of patients. A previous study in patients with advanced non-small-cell lung cancer showed that adenosine 5'-triphosphate (ATP) infusions had a favourable effect on fatigue, appetite, body weight, muscle strength, functional status and quality of life. The present study was designed 1. To evaluate whether ATP has favourable effects in terminally ill cancer patients, 2. To evaluate whether ATP infusions may reduce family caregiver burden and reduce the use of professional health care services, and 3. To test the feasibility of application of ATP infusions in a home care setting. METHODS/DESIGN: The study can be characterized as an open-labelled randomized controlled trial with two parallel groups. The intervention group received usual palliative care, two visits by an experienced dietician for advice, and regular ATP infusions over a period of 8 weeks. The control group received palliative care as usual and dietetic advice, but no ATP. This paper gives a description of the study design, selection of patients, interventions and outcome measures. DISCUSSION: From April 2002 through October 2006, a total of 100 patients have been randomized. Follow-up of patients will be completed in December 2006. At the time of writing, five patients are still in follow up. Of the 95 patients who have completed the study, 69 (73%) have completed four weeks of follow-up, and 53 (56%) have completed the full eight-week study period. The first results are expected in 2007.

AB - BACKGROUND: Palliative care in cancer aims at alleviating the suffering of patients. A previous study in patients with advanced non-small-cell lung cancer showed that adenosine 5'-triphosphate (ATP) infusions had a favourable effect on fatigue, appetite, body weight, muscle strength, functional status and quality of life. The present study was designed 1. To evaluate whether ATP has favourable effects in terminally ill cancer patients, 2. To evaluate whether ATP infusions may reduce family caregiver burden and reduce the use of professional health care services, and 3. To test the feasibility of application of ATP infusions in a home care setting. METHODS/DESIGN: The study can be characterized as an open-labelled randomized controlled trial with two parallel groups. The intervention group received usual palliative care, two visits by an experienced dietician for advice, and regular ATP infusions over a period of 8 weeks. The control group received palliative care as usual and dietetic advice, but no ATP. This paper gives a description of the study design, selection of patients, interventions and outcome measures. DISCUSSION: From April 2002 through October 2006, a total of 100 patients have been randomized. Follow-up of patients will be completed in December 2006. At the time of writing, five patients are still in follow up. Of the 95 patients who have completed the study, 69 (73%) have completed four weeks of follow-up, and 53 (56%) have completed the full eight-week study period. The first results are expected in 2007.

U2 - 10.1186/1471-2458-7-4

DO - 10.1186/1471-2458-7-4

M3 - Article

C2 - 17210069

SN - 1471-2458

VL - 7

SP - 4

JO - BMC Public Health

JF - BMC Public Health

ER -