Appetite and blood glucose profiles in humans after glycogen-depleting exercise.

K.J. Melanson, M.S. Westerterp-Plantenga*, L.A. Campfield, W.H.M. Saris

*Corresponding author for this work

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Department of Human Biology, Maastricht University, 6200 MD Maastricht, The Netherlands.

Regulatory functions of glycogen stores and blood glucose on human appetite, particularly relating to exercise, are not fully understood. Ten men (age 20-31 yr) performed glycogen-depleting exercise in an evening, ate a low-carbohydrate dinner, and stayed overnight in the laboratory. The next day, blood glucose was monitored continuously for 517 +/- 23 (SE) min. Subjects had access to high-fat and high-carbohydrate foods after baseline glucose and respiratory quotient were determined. In the afternoon, 1 h of moderate exercise was performed. Baseline respiratory quotient was 0. 748 +/- 0.008, plasma free fatty acids were 677 +/- 123 micromol/l, insulin was 4.8 +/- 0.5 microU/ml, and leptin was 1.9 +/- 0.3 ng/ml. Postabsorptively, 8 of 10 meals were initiated during stability in blood glucose. Postprandially, the association between meal initiation and blood glucose declines became significant (chi(2) = 7. 82). During moderate exercise, blood glucose initially decreased but recovered before completion. When the glycogen buffer is depleted, meal initiation can occur during blood glucose stability; the relationship between blood glucose declines and meal initiation reestablishes with refeeding.

Publication Types:
Clinical Trial
Original languageEnglish
Pages (from-to)947-953
Number of pages7
JournalJournal of Applied Physiology
Issue number3
Publication statusPublished - 1 Jan 1999


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