Apoptosis and inflammation in renal reperfusion injury

M.A.R.C. Daemen, B. de Vries, W.A. Buurman

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Apoptosis and inflammation in renal reperfusion injury.

Daemen MA, de Vries B, Buurman WA.

Department of General Surgery, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands.

Ischemia followed by reperfusion (I/R) has cardinal implications in the pathogenesis of organ transplantation and rejection. Apoptosis and inflammation are central mechanisms leading to organ damage in the course of renal I/R. General aspects of apoptosis, morphology, induction, and biochemistry are discussed. Activated caspases, the classical effector enzymes of apoptosis, are able to induce not only apoptosis but also inflammation after I/R in experimental models. This redefines the involvement of apoptosis in I/R injury toward a central and functional role in the development of organ damage. Our purpose is to assess aspects of apoptosis and inflammation in terms of involvement in the pathogenesis of I/R-induced organ damage. Moreover, the implications of recent experimental advances for diagnosis and treatment of renal I/R injury in clinical practice will be discussed.
Original languageEnglish
Pages (from-to)1693-1700
Number of pages7
JournalTransplantation
Volume73
Issue number11
DOIs
Publication statusPublished - 1 Jan 2002

Cite this

Daemen, M. A. R. C., de Vries, B., & Buurman, W. A. (2002). Apoptosis and inflammation in renal reperfusion injury. Transplantation, 73(11), 1693-1700. https://doi.org/10.1097/00007890-200206150-00001