Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction: An Analysis of the German Neonatal Network Cohort

Stephen Norda, Tanja K. Rausch, Thorsten Orlikowsky, Matthias Huetten, Soeren Schulz, Wolfgang Goepel, Ulrich Pecks*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Web of Science)

Abstract

Aim. Cord blood of intrauterine growth restricted (IUGR) neonates displays lipid changes towards atherosclerotic profiles. Apolipoprotein E (ApoE) and its isoforms (e2, e3, and e4) are involved in the regulation of lipid metabolism. Specifically, ApoE e4 has been associated with atherosclerotic diseases, while e2 has a favorable effect. We therefore hypothesized that ApoE e4 haplotype is frequently observed in IUGR neonates and contributes to impaired fetal growth and the association of IUGR with cardiovascular and metabolic diseases later in life. Methods. A cohort of 4885 preterm infants (>= 22+0 and 10th birth weight percentile. Analysis of the single nucleotides rs429358 and rs7412, identifying the ApoE genotype, was carried out using TaqMan (R) SNP genotyping assays. The proportional odds model was used to assess data. Results. No association was found between genotype and birth weight percentiles in each of the subgroups. Conclusion. ApoE genotype and low birth weight depict two distinct risk factors for cardiovascular disease without being directly associated.

Original languageEnglish
Article number2837027
Number of pages8
JournalBioMed Research International
Volume2017
DOIs
Publication statusPublished - 5 Apr 2017

Keywords

  • GESTATIONAL-AGE
  • CEREBRAL-PALSY
  • FETAL-GROWTH
  • CORD BLOOD
  • GENE POLYMORPHISMS
  • E ALLELES
  • PREECLAMPSIA
  • NEWBORN
  • PREGNANCY
  • SEVERITY

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