Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction: An Analysis of the German Neonatal Network Cohort

Stephen Norda; Tanja K. Rausch; Thorsten Orlikowsky; Matthias Huetten; Soeren Schulz; Wolfgang Goepel; Ulrich Pecks

doi:10.1155/2017/2837027

Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction: An Analysis of the German Neonatal Network Cohort

Stephen Norda, Tanja K. Rausch, Thorsten Orlikowsky, Matthias Huetten, Soeren Schulz, Wolfgang Goepel, Ulrich Pecks^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Aim. Cord blood of intrauterine growth restricted (IUGR) neonates displays lipid changes towards atherosclerotic profiles. Apolipoprotein E (ApoE) and its isoforms (e2, e3, and e4) are involved in the regulation of lipid metabolism. Specifically, ApoE e4 has been associated with atherosclerotic diseases, while e2 has a favorable effect. We therefore hypothesized that ApoE e4 haplotype is frequently observed in IUGR neonates and contributes to impaired fetal growth and the association of IUGR with cardiovascular and metabolic diseases later in life. Methods. A cohort of 4885 preterm infants (>= 22+0 and 10th birth weight percentile. Analysis of the single nucleotides rs429358 and rs7412, identifying the ApoE genotype, was carried out using TaqMan (R) SNP genotyping assays. The proportional odds model was used to assess data. Results. No association was found between genotype and birth weight percentiles in each of the subgroups. Conclusion. ApoE genotype and low birth weight depict two distinct risk factors for cardiovascular disease without being directly associated.

Original language	English
Article number	2837027
Number of pages	8
Journal	BioMed Research International
Volume	2017
DOIs	https://doi.org/10.1155/2017/2837027
Publication status	Published - 5 Apr 2017

Keywords

GESTATIONAL-AGE
CEREBRAL-PALSY
FETAL-GROWTH
CORD BLOOD
GENE POLYMORPHISMS
E ALLELES
PREECLAMPSIA
NEWBORN
PREGNANCY
SEVERITY

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@article{9f097f329fa2483bb53c0b4fc87d3293,

title = "Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction: An Analysis of the German Neonatal Network Cohort",

abstract = "Aim. Cord blood of intrauterine growth restricted (IUGR) neonates displays lipid changes towards atherosclerotic profiles. Apolipoprotein E (ApoE) and its isoforms (e2, e3, and e4) are involved in the regulation of lipid metabolism. Specifically, ApoE e4 has been associated with atherosclerotic diseases, while e2 has a favorable effect. We therefore hypothesized that ApoE e4 haplotype is frequently observed in IUGR neonates and contributes to impaired fetal growth and the association of IUGR with cardiovascular and metabolic diseases later in life. Methods. A cohort of 4885 preterm infants (>= 22+0 and 10th birth weight percentile. Analysis of the single nucleotides rs429358 and rs7412, identifying the ApoE genotype, was carried out using TaqMan (R) SNP genotyping assays. The proportional odds model was used to assess data. Results. No association was found between genotype and birth weight percentiles in each of the subgroups. Conclusion. ApoE genotype and low birth weight depict two distinct risk factors for cardiovascular disease without being directly associated.",

keywords = "GESTATIONAL-AGE, CEREBRAL-PALSY, FETAL-GROWTH, CORD BLOOD, GENE POLYMORPHISMS, E ALLELES, PREECLAMPSIA, NEWBORN, PREGNANCY, SEVERITY",

author = "Stephen Norda and Rausch, {Tanja K.} and Thorsten Orlikowsky and Matthias Huetten and Soeren Schulz and Wolfgang Goepel and Ulrich Pecks",

year = "2017",

month = apr,

day = "5",

doi = "10.1155/2017/2837027",

language = "English",

volume = "2017",

journal = "BioMed Research International",

issn = "2314-6133",

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T1 - Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction

T2 - An Analysis of the German Neonatal Network Cohort

AU - Norda, Stephen

AU - Rausch, Tanja K.

AU - Orlikowsky, Thorsten

AU - Huetten, Matthias

AU - Schulz, Soeren

AU - Goepel, Wolfgang

AU - Pecks, Ulrich

PY - 2017/4/5

Y1 - 2017/4/5

N2 - Aim. Cord blood of intrauterine growth restricted (IUGR) neonates displays lipid changes towards atherosclerotic profiles. Apolipoprotein E (ApoE) and its isoforms (e2, e3, and e4) are involved in the regulation of lipid metabolism. Specifically, ApoE e4 has been associated with atherosclerotic diseases, while e2 has a favorable effect. We therefore hypothesized that ApoE e4 haplotype is frequently observed in IUGR neonates and contributes to impaired fetal growth and the association of IUGR with cardiovascular and metabolic diseases later in life. Methods. A cohort of 4885 preterm infants (>= 22+0 and 10th birth weight percentile. Analysis of the single nucleotides rs429358 and rs7412, identifying the ApoE genotype, was carried out using TaqMan (R) SNP genotyping assays. The proportional odds model was used to assess data. Results. No association was found between genotype and birth weight percentiles in each of the subgroups. Conclusion. ApoE genotype and low birth weight depict two distinct risk factors for cardiovascular disease without being directly associated.

AB - Aim. Cord blood of intrauterine growth restricted (IUGR) neonates displays lipid changes towards atherosclerotic profiles. Apolipoprotein E (ApoE) and its isoforms (e2, e3, and e4) are involved in the regulation of lipid metabolism. Specifically, ApoE e4 has been associated with atherosclerotic diseases, while e2 has a favorable effect. We therefore hypothesized that ApoE e4 haplotype is frequently observed in IUGR neonates and contributes to impaired fetal growth and the association of IUGR with cardiovascular and metabolic diseases later in life. Methods. A cohort of 4885 preterm infants (>= 22+0 and 10th birth weight percentile. Analysis of the single nucleotides rs429358 and rs7412, identifying the ApoE genotype, was carried out using TaqMan (R) SNP genotyping assays. The proportional odds model was used to assess data. Results. No association was found between genotype and birth weight percentiles in each of the subgroups. Conclusion. ApoE genotype and low birth weight depict two distinct risk factors for cardiovascular disease without being directly associated.

KW - GESTATIONAL-AGE

KW - CEREBRAL-PALSY

KW - FETAL-GROWTH

KW - CORD BLOOD

KW - GENE POLYMORPHISMS

KW - E ALLELES

KW - PREECLAMPSIA

KW - NEWBORN

KW - PREGNANCY

KW - SEVERITY

U2 - 10.1155/2017/2837027

DO - 10.1155/2017/2837027

M3 - Article

C2 - 28480219

SN - 2314-6133

VL - 2017

JO - BioMed Research International

JF - BioMed Research International

M1 - 2837027

ER -

Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction: An Analysis of the German Neonatal Network Cohort

Abstract

Keywords

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