Apical CD36 immunolocalization in human and porcine taste buds from circumvallate and foliate papillae

Peter J. Simons*, J. Alain Kummer, Joost J. F. P. Luiken, Louis Boon

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

101 Citations (Web of Science)


CD36 is the receptor for long chain fatty acids (LCFA), and is expressed in lingual taste cells from rodents. In these animals, CD36 has been proposed to play an important role in oral detection of LCFA, and subsequently, determines their dietary fat preference. Humans also seem to detect LCFA in the oral cavity, however, information on the molecular mechanism of this human orosensory LCFA recognition is currently lacking. The aim of our study was to investigate whether CD36 is also expressed in lingual human and porcine taste buds cells. Using fluorescence immunohistochemistry, apical CD36 expression was revealed in human and porcine taste bud cells from circumvallate and foliate papillae. These data suggest CD36 as the putative orosensory receptor for dietary LCFA in human, and, therefore, may be involved in our preference for fatty foods.
Original languageEnglish
Pages (from-to)839-843
JournalActa Histochemica
Issue number8
Publication statusPublished - 2011


  • CD36
  • Orosensory receptor
  • Long chain fatty acids
  • Taste buds
  • Dietary fat preference
  • Obesity
  • Human

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