Aortic Customize: An In Vivo Feasibility Study of a Percutaneous Technique for the Repair of Aortic Aneurysms Using Injectable Elastomer

W. M. P. F. Bosman*, Andre J. Vlot, T. J. van der Steenhoven, J.W.O. van den Berg, Jaap F. Hamming, A. C. de Vries, Hans L. F. Brom, M. J. Jacobs

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Web of Science)

Abstract

Objective: This study aimed to test a percutaneous technique for aneurysm-sac filling by means of in situ polymerisation in an in vivo model. Design: Aortic Customize is a new endovascular treatment concept for aortic aneurysms: a non-cross-linked liquid elastomer is injected to fill the aneurysm sac around a balloon-catheter. With this method, a compliant elastomer mould with a patent lumen is created. Material: The formulation used in the experiments consisted of a two-component addition-cure liquid-silicone formulation, based on vinyl-terminated polydimethylsiloxane (PDMS). Methods: The concept of aneurysm-sac filling was tested in vivo in porcine experiments (n = 3). Results: In vivo porcine experiments with the sac-filling application showed successful exclusion of the created aneurysms with patent lumens and absence of endoleaks. The aneurysms were excluded successfully in the in vivo model, injecting elastomer through a 7-French catheter, filling up the entire aneurysm sac. Conclusions: These in vivo experiments demonstrate that the principle of aneurysm-sac filling by means of in situ curing is feasible, excluding the aneurysm and creating a new lumen. Further long-term animal experiments must be done prior to consideration of clinical application.
Original languageEnglish
Pages (from-to)65-70
JournalEuropean Journal of Vascular and Endovascular Surgery
Volume40
Issue number1
DOIs
Publication statusPublished - Jul 2010

Keywords

  • Abdominal aortic aneurysm
  • Aneurysm-sac filling
  • Endovascular aneurysm repair
  • In vivo study
  • Polydimethylsiloxane

Cite this