Anxiety in Parkinson's disease: A resting-state high density EEG study

Nacim Betrouni; Edouard Alazard; Madli Bayot; Guillaume Carey; Philippe Derambure; Luc Defebvre; Albert Fg Leentjens; Arnaud Delval; Kathy Dujardin

doi:10.1016/j.neucli.2022.01.001

Anxiety in Parkinson's disease: A resting-state high density EEG study

Nacim Betrouni^*, Edouard Alazard, Madli Bayot, Guillaume Carey, Philippe Derambure, Luc Defebvre, Albert Fg Leentjens, Arnaud Delval, Kathy Dujardin

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

OBJECTIVE: To identify markers of Parkinson's disease (PD) related anxiety, using high density electroencephalography (hd-EEG).

METHODS: 108 patients participated in the study. They were divided into two groups: with and without clinically relevant anxiety, according to their score on the Parkinson Anxiety Scale. Resting-state hd-EEG was recorded. Spectral and functional connectivity characteristics were compared between the two groups.

RESULTS: Thirty-three patients (31%) had significant anxiety symptoms. In the spectral analysis, relative power in the alpha1 frequency band in the right prefrontal cortex was lower in patients with anxiety than without. Functional connectivity analysis showed a stronger connectivity between the left insula and several regions of the right prefrontal cortex in patients with anxiety than in those without.

CONCLUSION: This study shows the pivotal role of the insula and frontal cortex in the pathophysiology of anxiety in PD and extends the results of previous studies using magnetic resonance imaging or positron emission tomography imaging.

Original language	English
Pages (from-to)	202-211
Number of pages	10
Journal	Neurophysiologie Clinique-Clinical Neurophysiology
Volume	52
Issue number	3
Early online date	15 Jan 2022
DOIs	https://doi.org/10.1016/j.neucli.2022.01.001
Publication status	Published - Jun 2022

Keywords

ALPHA-OSCILLATIONS
Anxiety disorders
CORRELATE
CORTEX
DISORDER
Electroencephalo-graphy
FUNCTIONAL CONNECTIVITY
Functional connectivity
RATING-SCALE
SYSTEM
Spectral analysis
VALIDATION

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Full TextFinal published version, 1.34 MBLicence: Taverne

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title = "Anxiety in Parkinson's disease: A resting-state high density EEG study",

abstract = "OBJECTIVE: To identify markers of Parkinson's disease (PD) related anxiety, using high density electroencephalography (hd-EEG).METHODS: 108 patients participated in the study. They were divided into two groups: with and without clinically relevant anxiety, according to their score on the Parkinson Anxiety Scale. Resting-state hd-EEG was recorded. Spectral and functional connectivity characteristics were compared between the two groups.RESULTS: Thirty-three patients (31%) had significant anxiety symptoms. In the spectral analysis, relative power in the alpha1 frequency band in the right prefrontal cortex was lower in patients with anxiety than without. Functional connectivity analysis showed a stronger connectivity between the left insula and several regions of the right prefrontal cortex in patients with anxiety than in those without.CONCLUSION: This study shows the pivotal role of the insula and frontal cortex in the pathophysiology of anxiety in PD and extends the results of previous studies using magnetic resonance imaging or positron emission tomography imaging.",

keywords = "ALPHA-OSCILLATIONS, Anxiety disorders, CORRELATE, CORTEX, DISORDER, Electroencephalo-graphy, FUNCTIONAL CONNECTIVITY, Functional connectivity, RATING-SCALE, SYSTEM, Spectral analysis, VALIDATION",

author = "Nacim Betrouni and Edouard Alazard and Madli Bayot and Guillaume Carey and Philippe Derambure and Luc Defebvre and Leentjens, {Albert Fg} and Arnaud Delval and Kathy Dujardin",

year = "2022",

month = jun,

doi = "10.1016/j.neucli.2022.01.001",

language = "English",

volume = "52",

pages = "202--211",

journal = "Neurophysiologie Clinique-Clinical Neurophysiology",

issn = "0987-7053",

publisher = "Elsevier Masson s.r.l.",

number = "3",

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T2 - A resting-state high density EEG study

AU - Betrouni, Nacim

AU - Alazard, Edouard

AU - Bayot, Madli

AU - Carey, Guillaume

AU - Derambure, Philippe

AU - Defebvre, Luc

AU - Leentjens, Albert Fg

AU - Delval, Arnaud

AU - Dujardin, Kathy

PY - 2022/6

Y1 - 2022/6

N2 - OBJECTIVE: To identify markers of Parkinson's disease (PD) related anxiety, using high density electroencephalography (hd-EEG).METHODS: 108 patients participated in the study. They were divided into two groups: with and without clinically relevant anxiety, according to their score on the Parkinson Anxiety Scale. Resting-state hd-EEG was recorded. Spectral and functional connectivity characteristics were compared between the two groups.RESULTS: Thirty-three patients (31%) had significant anxiety symptoms. In the spectral analysis, relative power in the alpha1 frequency band in the right prefrontal cortex was lower in patients with anxiety than without. Functional connectivity analysis showed a stronger connectivity between the left insula and several regions of the right prefrontal cortex in patients with anxiety than in those without.CONCLUSION: This study shows the pivotal role of the insula and frontal cortex in the pathophysiology of anxiety in PD and extends the results of previous studies using magnetic resonance imaging or positron emission tomography imaging.

AB - OBJECTIVE: To identify markers of Parkinson's disease (PD) related anxiety, using high density electroencephalography (hd-EEG).METHODS: 108 patients participated in the study. They were divided into two groups: with and without clinically relevant anxiety, according to their score on the Parkinson Anxiety Scale. Resting-state hd-EEG was recorded. Spectral and functional connectivity characteristics were compared between the two groups.RESULTS: Thirty-three patients (31%) had significant anxiety symptoms. In the spectral analysis, relative power in the alpha1 frequency band in the right prefrontal cortex was lower in patients with anxiety than without. Functional connectivity analysis showed a stronger connectivity between the left insula and several regions of the right prefrontal cortex in patients with anxiety than in those without.CONCLUSION: This study shows the pivotal role of the insula and frontal cortex in the pathophysiology of anxiety in PD and extends the results of previous studies using magnetic resonance imaging or positron emission tomography imaging.

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KW - Anxiety disorders

KW - CORRELATE

KW - CORTEX

KW - DISORDER

KW - Electroencephalo-graphy

KW - FUNCTIONAL CONNECTIVITY

KW - Functional connectivity

KW - RATING-SCALE

KW - SYSTEM

KW - Spectral analysis

KW - VALIDATION

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DO - 10.1016/j.neucli.2022.01.001

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JO - Neurophysiologie Clinique-Clinical Neurophysiology

JF - Neurophysiologie Clinique-Clinical Neurophysiology

IS - 3

ER -

Anxiety in Parkinson's disease: A resting-state high density EEG study

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Keywords

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