Abstract

Psychiatric comorbidity is common in patients with chronic pain. In peripheral neuropathic pain, particularly anxiety and mood disorders are frequently present and associated with a high level of catastrophizing. Small fiber neuropathy (SFN) is a peripheral neuropathy dominated by pain. This study aimed to investigate the prevalence of and factors associated with anxiety and depressive symptoms in SFN. All consecutive patients diagnosed with SFN at Maastricht University Medical Center+, between September 2016 and October 2021, were included (n = 1310). Data on demographics, medical history, diagnostic tests, and questionnaires about pain, SFN-specific symptoms, and mental health were collected once. The Hospital Anxiety and Depression Scale (HADS) was used to measure anxiety and depression and the Pain Catastrophizing Scale (PCS) to measure the degree of catastrophizing. One-third of the patients had an abnormal HADS score (>= 11) on the subscales anxiety and/or depression (26.5% anxiety and 23.0% depression) indicating clinical relevance. Regression analysis showed that higher pain intensity, catastrophizing, and more SFN-related complaints were significantly associated with an abnormal HADS-score. In conclusion, the prevalence of reported anxiety or depressive symptoms in SFN is 36.3%. A multidisciplinary approach, not only focusing on pain relief, is therefore essential for the treatment of SFN.
Original languageEnglish
Pages (from-to)291-301
Number of pages11
JournalJournal of the Peripheral Nervous System
Volume27
Issue number4
Early online date1 Oct 2022
DOIs
Publication statusPublished - Dec 2022

Keywords

  • anxiety
  • association
  • depression
  • neuropathic pain
  • small fiber neuropathy
  • QUALITY-OF-LIFE
  • CHRONIC PAIN
  • GENDER-DIFFERENCES
  • DIAGNOSTIC-CRITERIA
  • HOSPITAL ANXIETY
  • MENTAL-ILLNESS
  • IMPACT
  • HEALTH
  • DISORDERS
  • COMORBIDITY

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