AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice

Mathias Burgmaier; Kristof Schutters; Brecht Willems; Emiel P. C. Van der Vorst; Dennis Kusters; Martijn Chatrou; Lucy Norling; Erik A. L. Biessen; Jack Cleutjens; Mauro Perretti; Leon J. Schurgers; Christiaan Reutelingsperger

doi:10.1111/jcmm.12374

AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice

Mathias Burgmaier, Kristof Schutters, Brecht Willems, Emiel P. C. Van der Vorst, Dennis Kusters, Martijn Chatrou, Lucy Norling, Erik A. L. Biessen, Jack Cleutjens, Mauro Perretti, Leon J. Schurgers, Christiaan Reutelingsperger^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Annexin A5 (AnxA5) exerts anti-inflammatory, anticoagulant and anti-apoptotic effects through binding cell surface expressed phosphatidylserine. The actions of AnxA5 on atherosclerosis are incompletely understood. We investigated effects of exogenous AnxA5 on plaque morphology and phenotype of advanced atherosclerotic lesions in apoE(-/-) mice. Advanced atherosclerotic lesions were induced in 12weeks old Western type diet fed apoE(-/-) mice using a collar placement around the carotid artery. After 5weeks mice were injected either with AnxA5 (n=8) or vehicle for another 4weeks. AnxA5 reduced plaque macrophage content both in the intima (59% reduction, P

Original language	English
Pages (from-to)	2117-2124
Journal	Journal of Cellular and Molecular Medicine
Volume	18
Issue number	10
DOIs	https://doi.org/10.1111/jcmm.12374
Publication status	Published - Oct 2014

Keywords

atherosclerosis
annexin A5
plaque inflammation
phosphatidylserine
apoptosis

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Cite this

Burgmaier, M., Schutters, K., Willems, B., Van der Vorst, E. P. C., Kusters, D., Chatrou, M., Norling, L., Biessen, E. A. L., Cleutjens, J., Perretti, M., Schurgers, L. J., & Reutelingsperger, C. (2014). AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice. Journal of Cellular and Molecular Medicine, 18(10), 2117-2124. https://doi.org/10.1111/jcmm.12374

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title = "AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice",

abstract = "Annexin A5 (AnxA5) exerts anti-inflammatory, anticoagulant and anti-apoptotic effects through binding cell surface expressed phosphatidylserine. The actions of AnxA5 on atherosclerosis are incompletely understood. We investigated effects of exogenous AnxA5 on plaque morphology and phenotype of advanced atherosclerotic lesions in apoE(-/-) mice. Advanced atherosclerotic lesions were induced in 12weeks old Western type diet fed apoE(-/-) mice using a collar placement around the carotid artery. After 5weeks mice were injected either with AnxA5 (n=8) or vehicle for another 4weeks. AnxA5 reduced plaque macrophage content both in the intima (59% reduction, P",

keywords = "atherosclerosis, annexin A5, plaque inflammation, phosphatidylserine, apoptosis",

author = "Mathias Burgmaier and Kristof Schutters and Brecht Willems and {Van der Vorst}, {Emiel P. C.} and Dennis Kusters and Martijn Chatrou and Lucy Norling and Biessen, {Erik A. L.} and Jack Cleutjens and Mauro Perretti and Schurgers, {Leon J.} and Christiaan Reutelingsperger",

year = "2014",

month = oct,

doi = "10.1111/jcmm.12374",

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journal = "Journal of Cellular and Molecular Medicine",

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Burgmaier, M, Schutters, K, Willems, B, Van der Vorst, EPC, Kusters, D, Chatrou, M, Norling, L, Biessen, EAL , Cleutjens, J, Perretti, M, Schurgers, LJ & Reutelingsperger, C 2014, 'AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice', Journal of Cellular and Molecular Medicine, vol. 18, no. 10, pp. 2117-2124. https://doi.org/10.1111/jcmm.12374

TY - JOUR

T1 - AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice

AU - Burgmaier, Mathias

AU - Schutters, Kristof

AU - Willems, Brecht

AU - Van der Vorst, Emiel P. C.

AU - Kusters, Dennis

AU - Chatrou, Martijn

AU - Norling, Lucy

AU - Biessen, Erik A. L.

AU - Cleutjens, Jack

AU - Perretti, Mauro

AU - Schurgers, Leon J.

AU - Reutelingsperger, Christiaan

PY - 2014/10

Y1 - 2014/10

N2 - Annexin A5 (AnxA5) exerts anti-inflammatory, anticoagulant and anti-apoptotic effects through binding cell surface expressed phosphatidylserine. The actions of AnxA5 on atherosclerosis are incompletely understood. We investigated effects of exogenous AnxA5 on plaque morphology and phenotype of advanced atherosclerotic lesions in apoE(-/-) mice. Advanced atherosclerotic lesions were induced in 12weeks old Western type diet fed apoE(-/-) mice using a collar placement around the carotid artery. After 5weeks mice were injected either with AnxA5 (n=8) or vehicle for another 4weeks. AnxA5 reduced plaque macrophage content both in the intima (59% reduction, P

AB - Annexin A5 (AnxA5) exerts anti-inflammatory, anticoagulant and anti-apoptotic effects through binding cell surface expressed phosphatidylserine. The actions of AnxA5 on atherosclerosis are incompletely understood. We investigated effects of exogenous AnxA5 on plaque morphology and phenotype of advanced atherosclerotic lesions in apoE(-/-) mice. Advanced atherosclerotic lesions were induced in 12weeks old Western type diet fed apoE(-/-) mice using a collar placement around the carotid artery. After 5weeks mice were injected either with AnxA5 (n=8) or vehicle for another 4weeks. AnxA5 reduced plaque macrophage content both in the intima (59% reduction, P

KW - atherosclerosis

KW - annexin A5

KW - plaque inflammation

KW - phosphatidylserine

KW - apoptosis

U2 - 10.1111/jcmm.12374

DO - 10.1111/jcmm.12374

M3 - Article

C2 - 25214012

SN - 1582-1838

VL - 18

SP - 2117

EP - 2124

JO - Journal of Cellular and Molecular Medicine

JF - Journal of Cellular and Molecular Medicine

IS - 10

ER -