Abstract
The history of anti-neutrophil cytoplasmic antibodies (ANCA) starts with an association with glomerulonephritis and is followed by proving that ANCA play a pathogenic role in ANCA-associated vasculitis (AAV). While ANCA initially where detected by indirect immunofluorescence (IIF) testing, the discovery of the auto-antigens, i.e., myeloperoxidase and proteinase 3, resulted in an evolution in ANCA testing that nowadays have better test-characteristics than the original IIF test. For several decades ANCA have a clear position in the diagnostic work-up of AAV, but recently ANCA have also been included in the classification criteria for the AAV subtypes. The interpretation of test results could in the near future
be further facilitated by reporting of likelihood ratios for test result intervals. The role of ANCA in the follow-up of patients, however, remains a matter of
discussion and requires further investigation.
be further facilitated by reporting of likelihood ratios for test result intervals. The role of ANCA in the follow-up of patients, however, remains a matter of
discussion and requires further investigation.
| Translated title of the contribution | Anti-neutrophil cytoplasmic antibodies in small vessel vasculitis: a historical overview |
|---|---|
| Original language | Dutch |
| Pages (from-to) | 78-85 |
| Number of pages | 8 |
| Journal | Nederlands tijdschrift voor allergie, astma en klinische immunologie |
| Volume | 23 |
| Issue number | 3 |
| Publication status | Published - Sept 2023 |