Antibiotics-induced obesity: A mitochondrial perspective

M.J. Andrade, C. Jayaprakash, S. Bhat, N. Evangelatos, A. Brand, K. Satyamoorthy*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Antibiotics are the first line of treatment against infections and have contributed immensely to reduce the morbidity and mortality rates. Recently, extensive use of antibiotics has led to alterations of the gut microbiome, predisposition to various diseases and most importantly, increase in the emergence of antibiotic-resistant bacteria, which poses a major threat to global public health. Another major issue faced worldwide due to unregulated use of antibiotics in children as well as in adults is the influence of metabolism and body weight homeostasis, leading to obesity. Apart from the involvement of biosocial causes influencing diet, physical activity, and antibiotic use, pathogenesis of obesity is linked to interconnected functional alterations in cells, tissues and organs due to biochemical, epigenetic and genetic factors. Mitochondrial dysfunction is one such factor, which is becoming the primary focus of various aspects of research on multifactorial complex diseases and is providing new perspectives on etiology, biomarker-based diagnosis, and drug sensitivity Through this review, we have made an attempt to present the interplay between use of antibiotics, obesity, and associated mitochondrial dysfunction. This may provide insights into the molecular basis, genetic predisposition and environmental triggers, which in turn may have potential clinical applications in the management of antibiotic use. (c) 2017 S. Karger AG, Basel

Original languageEnglish
Pages (from-to)257-273
Number of pages17
JournalPublic Health Genomics
Volume20
Issue number5
DOIs
Publication statusPublished - 2017

JEL classifications

  • i19 - Health: Other
  • i18 - "Health: Government Policy; Regulation; Public Health"

Keywords

  • Antibiotic resistance
  • Mitochondrial dysfunction
  • Non-sense-mediated decay
  • Obesity
  • Public health issues
  • antibiotic agent
  • cytokine
  • matrix metalloproteinase
  • mitochondrial DNA
  • disorders of mitochondrial functions
  • drug efficacy
  • drug induced disease
  • drug use
  • gene mutation
  • human
  • nonhuman
  • nonsense mediated mRNA decay
  • obesity
  • pathogenesis
  • priority journal
  • Review
  • RIBOSOMAL-RNA
  • PREMATURE STOP MUTATIONS
  • NONSENSE-MEDIATED DECAY
  • MESSENGER-RNA DECAY
  • GUT MICROBIOTA
  • BLOOD MONONUCLEAR-CELLS
  • MATRIX METALLOPROTEINASES
  • FREE FATTY-ACIDS
  • BODY-MASS INDEX
  • CHILDHOOD OBESITY

Cite this

Andrade, M. J., Jayaprakash, C., Bhat, S., Evangelatos, N., Brand, A., & Satyamoorthy, K. (2017). Antibiotics-induced obesity: A mitochondrial perspective. Public Health Genomics, 20(5), 257-273. https://doi.org/10.1159/000485095