Antiangiogenic factors and maternal hemodynamics during intensive hemodialysis in pregnancy.

T. Cornelis*, M.E.A. Spaanderman, C. Beerenhout, F.H. Perschel, S. Verlohren, C.G. Schalkwijk, F.M. van der Sande, J.P. Kooman, M. Hladunewich

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


We report on a 21-year-old pregnant patient with IgA nephropathy who was initiated on intensive hemodialysis (8 hours of hemodialysis 3 times a gestational age of 26 weeks on the basis of worsening kidney function in rapidly progressive fatigue and difficulties in metabolic control. the pregnancy, and while on intensive hemodialysis, 24-hour ambulatory pressure control was within the target, and results of weekly 24-hour of central hemodynamics and pulse wave velocity, and of serial levels of circulating (anti-)angiogenic factors were comparable to normal Estimated fetal growth evolved along the 50th percentile, and no was detected. After induction for a sudden, unexplained increase in pressure, she delivered a healthy boy of 2480 g at a gestational age of This case adds to the expanding literature that supports the use of hemodialysis in pregnant patients with end-stage renal disease and for the first time, the potential use of serial (anti-) angiogenic 24-hour measurements of blood pressure and hemodynamic indices in order facilitate monitoring of these complicated patients.
Original languageEnglish
Pages (from-to)639-643
JournalHemodialysis international
Issue number4
Publication statusPublished - 1 Jan 2013


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