Anti-Sm antibodies in the classification criteria of systemic lupus erythematosus

Joyce J B C van Beers; Marco W J Schreurs

doi:10.1016/j.jtauto.2022.100155

Anti-Sm antibodies in the classification criteria of systemic lupus erythematosus

Joyce J B C van Beers^*, Marco W J Schreurs

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Systemic lupus erythematosus is characterized by autoantibodies and immune complex deposition. Several autoantibodies against mainly nuclear autoantigens have been described. One of these nuclear autoantigens is the Smith antigen. In this review, we focus on the position of autoantibodies against the Smith antigen in the classification criteria, the characteristics of the antigen, the production of anti-Smith antibodies in SLE and we discuss the different test methods available, together with their pitfalls, to detect these autoantibodies.

Original language	English
Article number	100155
Number of pages	6
Journal	Journal of Translational Autoimmunity
Volume	5
DOIs	https://doi.org/10.1016/j.jtauto.2022.100155
Publication status	Published - 2022

Keywords

Systemic lupus erythematosus
Classification criteria
Smith antigen
CIRCULATING IMMUNE-COMPLEXES
EPSTEIN-BARR-VIRUS
AUTOANTIBODIES
IMMUNOASSAY
DIFFERENTIATION
IDENTIFICATION
PERFORMANCE
PATTERNS
SEQUENCE
DISEASE

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title = "Anti-Sm antibodies in the classification criteria of systemic lupus erythematosus",

abstract = "Systemic lupus erythematosus is characterized by autoantibodies and immune complex deposition. Several autoantibodies against mainly nuclear autoantigens have been described. One of these nuclear autoantigens is the Smith antigen. In this review, we focus on the position of autoantibodies against the Smith antigen in the classification criteria, the characteristics of the antigen, the production of anti-Smith antibodies in SLE and we discuss the different test methods available, together with their pitfalls, to detect these autoantibodies.",

keywords = "Systemic lupus erythematosus, Classification criteria, Smith antigen, CIRCULATING IMMUNE-COMPLEXES, EPSTEIN-BARR-VIRUS, AUTOANTIBODIES, IMMUNOASSAY, DIFFERENTIATION, IDENTIFICATION, PERFORMANCE, PATTERNS, SEQUENCE, DISEASE",

author = "{van Beers}, {Joyce J B C} and Schreurs, {Marco W J}",

note = "{\textcopyright} 2022 The Authors.",

year = "2022",

doi = "10.1016/j.jtauto.2022.100155",

language = "English",

volume = "5",

journal = "Journal of Translational Autoimmunity",

issn = "2589-9090",

publisher = "Elsevier",

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T1 - Anti-Sm antibodies in the classification criteria of systemic lupus erythematosus

AU - van Beers, Joyce J B C

AU - Schreurs, Marco W J

PY - 2022

Y1 - 2022

N2 - Systemic lupus erythematosus is characterized by autoantibodies and immune complex deposition. Several autoantibodies against mainly nuclear autoantigens have been described. One of these nuclear autoantigens is the Smith antigen. In this review, we focus on the position of autoantibodies against the Smith antigen in the classification criteria, the characteristics of the antigen, the production of anti-Smith antibodies in SLE and we discuss the different test methods available, together with their pitfalls, to detect these autoantibodies.

AB - Systemic lupus erythematosus is characterized by autoantibodies and immune complex deposition. Several autoantibodies against mainly nuclear autoantigens have been described. One of these nuclear autoantigens is the Smith antigen. In this review, we focus on the position of autoantibodies against the Smith antigen in the classification criteria, the characteristics of the antigen, the production of anti-Smith antibodies in SLE and we discuss the different test methods available, together with their pitfalls, to detect these autoantibodies.

KW - Systemic lupus erythematosus

KW - Classification criteria

KW - Smith antigen

KW - CIRCULATING IMMUNE-COMPLEXES

KW - EPSTEIN-BARR-VIRUS

KW - AUTOANTIBODIES

KW - IMMUNOASSAY

KW - DIFFERENTIATION

KW - IDENTIFICATION

KW - PERFORMANCE

KW - PATTERNS

KW - SEQUENCE

KW - DISEASE

U2 - 10.1016/j.jtauto.2022.100155

DO - 10.1016/j.jtauto.2022.100155

M3 - Article

C2 - 35464346

SN - 2589-9090

VL - 5

JO - Journal of Translational Autoimmunity

JF - Journal of Translational Autoimmunity

M1 - 100155

ER -

Anti-Sm antibodies in the classification criteria of systemic lupus erythematosus

Abstract

Keywords

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