Anti-osteoporosis drug prescribing after hip fracture in the UK: 2000-2010

C. Klop, D. Gibson-Smith, P.J.M. Elders, P.M.J. Welsing, H.G.M. Leufkens, N.C. Harvey, J.W.J. Bijlsma, T.P. van Staa, F. de Vries*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


The probability of initiating with anti-osteoporosis therapy increased from 7 % in 2000 to 46 % in 2010. This improvement was greater for patients over the age of 75 years. Men, those overweight, having dementia or exposed to antipsychotics, sedatives/hypnotics or opioid analgesics were significantly less likely to receive anti-osteoporosis drugs.

Introduction The objective of this study was to examine trends and determinants of anti-osteoporosis drug prescribing after hip fracture in the UK between 2000 and 2010.

Methods Data were extracted from the UK Clinical Practice Research Datalink for patients >= 50 years who had a first hip fracture between 2000 and 2010 and who did not currently (

Results The probability of being prescribed any anti-osteoporosis drug after hip fracture increased from 7 % in 2000 to 46 % in 2010. This trend was more marked in patients >= 75 years. The increase in prescribing of anti-osteoporosis drugs was complemented by a similar increase in vitamin D/calcium provision. Cumulative incidence of receiving anti-osteoporosis therapy was greater at any given point in time in women (8 % in 2000, 51 % in 2010) compared to men (4 % in 2000, 34 % in 2010). In addition to male gender, multivariable Cox regression identified reduced likelihood of receiving anti-osteoporosis drugs for those being overweight, having dementia and exposed to psychotropic drugs (antipsychotics, sedatives/hypnotics) or opioid analgesics.

Conclusion Although the prescribing of anti-osteoporosis drugs after hip fracture has increased substantially since 2000, the overall rate remained inadequate, particularly in men. With the continuing increase in the absolute number of hip fractures, further research should be made into the barriers to optimise osteoporosis management.

Original languageEnglish
Pages (from-to)1919-1928
Number of pages10
JournalOsteoporosis International
Issue number7
Publication statusPublished - Jul 2015


  • Anti-osteoporotic drugs
  • Bisphosphonate
  • Osteoporosis
  • Osteoporotic fracture
  • RISK
  • CARE

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