Antenatal Workup of Early Megacystis and Selection of Candidates for Fetal Therapy

Federica Fontanella; Leonie Duin; Phebe N. Adama van Scheltema; Titia E. Cohen-Overbeek; Eva Pajkrt; Mireille Bekker; Christine Willekes; Caroline J. Bax; Dick Oepkes; Catia M. Bilardo

doi:10.1159/000488282

Antenatal Workup of Early Megacystis and Selection of Candidates for Fetal Therapy

Federica Fontanella^*, Leonie Duin, Phebe N. Adama van Scheltema, Titia E. Cohen-Overbeek, Eva Pajkrt, Mireille Bekker, Christine Willekes, Caroline J. Bax, Dick Oepkes, Catia M. Bilardo

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective: To investigate the best criteria for discriminating fetuses with isolated posterior urethral valves from those theoretically not eligible for fetal treatment because of complex megacystis, high chance of spontaneous resolution, and urethral atresia. Methods: A retrospective national study was conducted in fetuses with megacystis detected before 17 weeks' gestation (early megacystis). Results: In total, 142 cases with fetal megacystis were included in the study: 52 with lower urinary tract obstruction, 29 with normal micturition at birth, and 61 with miscellaneous syndromal associations, chromosomal and multiple structural abnormalities (complex megacystis). Only a nuchal translucency >95th centile, and not a longitudinal bladder diameter 12 mm, and without ultrasound evidence of umbilical cord cysts. (C) 2018 The Author(s) Published by S. Karger AG, Basel

Original language	English
Pages (from-to)	155-161
Number of pages	7
Journal	Fetal Diagnosis and Therapy
Volume	45
Issue number	3
DOIs	https://doi.org/10.1159/000488282
Publication status	Published - 2019

Keywords

Megacystis
First-trimester pregnancy
Lower urinary tract obstructions
Posterior urethral valves
URINARY-TRACT OBSTRUCTION
PATENT URACHUS
1ST TRIMESTER
CYSTOSCOPY
GESTATION
FETUSES
CYST

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@article{31494b8e59a24c74a48ca3b164480708,

title = "Antenatal Workup of Early Megacystis and Selection of Candidates for Fetal Therapy",

abstract = "Objective: To investigate the best criteria for discriminating fetuses with isolated posterior urethral valves from those theoretically not eligible for fetal treatment because of complex megacystis, high chance of spontaneous resolution, and urethral atresia. Methods: A retrospective national study was conducted in fetuses with megacystis detected before 17 weeks' gestation (early megacystis). Results: In total, 142 cases with fetal megacystis were included in the study: 52 with lower urinary tract obstruction, 29 with normal micturition at birth, and 61 with miscellaneous syndromal associations, chromosomal and multiple structural abnormalities (complex megacystis). Only a nuchal translucency >95th centile, and not a longitudinal bladder diameter 12 mm, and without ultrasound evidence of umbilical cord cysts. (C) 2018 The Author(s) Published by S. Karger AG, Basel",

keywords = "Megacystis, First-trimester pregnancy, Lower urinary tract obstructions, Posterior urethral valves, URINARY-TRACT OBSTRUCTION, PATENT URACHUS, 1ST TRIMESTER, CYSTOSCOPY, GESTATION, FETUSES, CYST",

author = "Federica Fontanella and Leonie Duin and {van Scheltema}, {Phebe N. Adama} and Cohen-Overbeek, {Titia E.} and Eva Pajkrt and Mireille Bekker and Christine Willekes and Bax, {Caroline J.} and Dick Oepkes and Bilardo, {Catia M.}",

note = "Publisher Copyright: {\textcopyright} 2018 The Author(s) Published by S. Karger AG, Basel.",

year = "2019",

doi = "10.1159/000488282",

language = "English",

volume = "45",

pages = "155--161",

journal = "Fetal Diagnosis and Therapy",

issn = "1015-3837",

publisher = "Karger",

number = "3",

}

TY - JOUR

T1 - Antenatal Workup of Early Megacystis and Selection of Candidates for Fetal Therapy

AU - Fontanella, Federica

AU - Duin, Leonie

AU - van Scheltema, Phebe N. Adama

AU - Cohen-Overbeek, Titia E.

AU - Pajkrt, Eva

AU - Bekker, Mireille

AU - Willekes, Christine

AU - Bax, Caroline J.

AU - Oepkes, Dick

AU - Bilardo, Catia M.

PY - 2019

Y1 - 2019

N2 - Objective: To investigate the best criteria for discriminating fetuses with isolated posterior urethral valves from those theoretically not eligible for fetal treatment because of complex megacystis, high chance of spontaneous resolution, and urethral atresia. Methods: A retrospective national study was conducted in fetuses with megacystis detected before 17 weeks' gestation (early megacystis). Results: In total, 142 cases with fetal megacystis were included in the study: 52 with lower urinary tract obstruction, 29 with normal micturition at birth, and 61 with miscellaneous syndromal associations, chromosomal and multiple structural abnormalities (complex megacystis). Only a nuchal translucency >95th centile, and not a longitudinal bladder diameter 12 mm, and without ultrasound evidence of umbilical cord cysts. (C) 2018 The Author(s) Published by S. Karger AG, Basel

AB - Objective: To investigate the best criteria for discriminating fetuses with isolated posterior urethral valves from those theoretically not eligible for fetal treatment because of complex megacystis, high chance of spontaneous resolution, and urethral atresia. Methods: A retrospective national study was conducted in fetuses with megacystis detected before 17 weeks' gestation (early megacystis). Results: In total, 142 cases with fetal megacystis were included in the study: 52 with lower urinary tract obstruction, 29 with normal micturition at birth, and 61 with miscellaneous syndromal associations, chromosomal and multiple structural abnormalities (complex megacystis). Only a nuchal translucency >95th centile, and not a longitudinal bladder diameter 12 mm, and without ultrasound evidence of umbilical cord cysts. (C) 2018 The Author(s) Published by S. Karger AG, Basel

KW - Megacystis

KW - First-trimester pregnancy

KW - Lower urinary tract obstructions

KW - Posterior urethral valves

KW - URINARY-TRACT OBSTRUCTION

KW - PATENT URACHUS

KW - 1ST TRIMESTER

KW - CYSTOSCOPY

KW - GESTATION

KW - FETUSES

KW - CYST

U2 - 10.1159/000488282

DO - 10.1159/000488282

M3 - Article

C2 - 29772579

SN - 1015-3837

VL - 45

SP - 155

EP - 161

JO - Fetal Diagnosis and Therapy

JF - Fetal Diagnosis and Therapy

IS - 3

ER -

Antenatal Workup of Early Megacystis and Selection of Candidates for Fetal Therapy

Abstract

Keywords

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