Antenatal Workup of Early Megacystis and Selection of Candidates for Fetal Therapy

Federica Fontanella*, Leonie Duin, Phebe N. Adama van Scheltema, Titia E. Cohen-Overbeek, Eva Pajkrt, Mireille Bekker, Christine Willekes, Caroline J. Bax, Dick Oepkes, Catia M. Bilardo

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Web of Science)

Abstract

Objective: To investigate the best criteria for discriminating fetuses with isolated posterior urethral valves from those theoretically not eligible for fetal treatment because of complex megacystis, high chance of spontaneous resolution, and urethral atresia. Methods: A retrospective national study was conducted in fetuses with megacystis detected before 17 weeks' gestation (early megacystis). Results: In total, 142 cases with fetal megacystis were included in the study: 52 with lower urinary tract obstruction, 29 with normal micturition at birth, and 61 with miscellaneous syndromal associations, chromosomal and multiple structural abnormalities (complex megacystis). Only a nuchal translucency >95th centile, and not a longitudinal bladder diameter 12 mm, and without ultrasound evidence of umbilical cord cysts. (C) 2018 The Author(s) Published by S. Karger AG, Basel

Original languageEnglish
Pages (from-to)155-161
Number of pages7
JournalFetal Diagnosis and Therapy
Volume45
Issue number3
DOIs
Publication statusPublished - 2019

Keywords

  • Megacystis
  • First-trimester pregnancy
  • Lower urinary tract obstructions
  • Posterior urethral valves
  • URINARY-TRACT OBSTRUCTION
  • PATENT URACHUS
  • 1ST TRIMESTER
  • CYSTOSCOPY
  • GESTATION
  • FETUSES
  • CYST

Cite this