Answering biological questions: querying a systems biology database for nutrigenomics

C.T.A. Evelo, G.S. van Bochove, J.T. Saito

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The requirement of systems biology for connecting different levels of biological research leads directly to a need for integrating vast amounts of diverse information in general and of omics data in particular. The nutritional phenotype database addresses this challenge for nutrigenomics. A particularly urgent objective in coping with the data avalanche is making biologically meaningful information accessible to the researcher. This contribution describes how we intend to meet this objective with the nutritional phenotype database. We outline relevant parts of the system architecture, describe the kinds of data managed by it, and show how the system can support retrieval of biologically meaningful information by means of ontologies, full-text queries, and structured queries. Our contribution points out critical points, describes several technical hurdles. It demonstrates how pathway analysis can improve queries and comparisons for nutrition studies. Finally, three directions for future research are given.

Original languageEnglish
Pages (from-to)81-87
Number of pages7
JournalGenes and nutrition
Volume6
Issue number1
DOIs
Publication statusPublished - Feb 2011

Keywords

  • Querying
  • Bioinformatics
  • Nutrigenomics
  • Systems biology
  • Biological databases
  • GENE ONTOLOGY
  • MICROARRAY
  • RESOURCES
  • PATHWAYS
  • SERVICES
  • SUPPORT
  • SUITE

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