Abstract
Cardiac resynchronization therapy (CRT) is an important therapy for patients with heart failure and conduction pathology, but the benefits are heterogeneous between patients and approximately a third of patients do not show signs of clinical or echocardiographic response. This calls for a better understanding of the underlying conduction disease and resynchronization. In this review, we discuss to what extent established and novel animal models can help to better understand the pathophysiology of dyssynchrony and the benefits of CRT.
Original language | English |
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Pages (from-to) | 135-145 |
Journal | Journal of Cardiovascular Translational Research |
Volume | 5 |
Issue number | 2 |
DOIs | |
Publication status | Published - Apr 2012 |
Keywords
- Left bundle branch block
- Dyssynchrony
- Animal research
- Cardiac resynchronization therapy