Animal Models of Dyssynchrony

Marc Strik*, Lars B. van Middendorp, Kevin Vernooy

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Cardiac resynchronization therapy (CRT) is an important therapy for patients with heart failure and conduction pathology, but the benefits are heterogeneous between patients and approximately a third of patients do not show signs of clinical or echocardiographic response. This calls for a better understanding of the underlying conduction disease and resynchronization. In this review, we discuss to what extent established and novel animal models can help to better understand the pathophysiology of dyssynchrony and the benefits of CRT.
Original languageEnglish
Pages (from-to)135-145
JournalJournal of Cardiovascular Translational Research
Issue number2
Publication statusPublished - Apr 2012


  • Left bundle branch block
  • Dyssynchrony
  • Animal research
  • Cardiac resynchronization therapy


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