Animal-free strategies in food safety & nutrition: What are we waiting for? Part I: Food safety

Alie De Boer, Lisette Krul, Markus Fehr, Lucie Geurts*, Nynke Kramer, Maria Tabernero Urbieta, Johanneke Van Der Harst, Bob Van De Water, Koen Venema, Katrin Schütte, Paul A. Hepburn

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Web of Science)

Abstract

Background: Methods and approaches that can be used in toxicology and safety assessment are changing at a faster pace than ever. Members of the International Life Sciences Institute (ILSI) Europe have formed an expert group to review possibilities, opportunities and challenges for the potential use of non-animal testing strategies in food safety and nutrition research, which can ultimately be used in support of regulatory submissions for pre-market authorisation.

Scope and approach: For the different areas of food improvement agents, genetically modified foods and novel foods, the acceptability of non-animal strategies is evaluated in comparison to legislative requirements in Europe. Current hazard and risk assessment tools that do not require additional animal testing are reviewed and emerging tools and methodologies considered, covering advanced in vitro methods, in silico and system biology approaches and high-throughput methods for mode-of-action assessment.

Conclusions: The paper highlights the great potential for research strategies to be developed that reduce or avoid the use of animal tests, with the generation of more human-relevant data from multiple sources. It also shows the discordance in current legislation: on one hand saying non-animal strategies should be used, but on the other hand not providing sufficient guidance, leading in practice to lack of use of these non-animal testing strategies. This emphasizes the need for scientific developments and acceptability to be more reflected in legislation (e.g. guidance). What are we waiting for?

Original languageEnglish
Pages (from-to)469-484
Number of pages16
JournalTrends in Food Science & Technology
Volume106
DOIs
Publication statusPublished - Dec 2020

Keywords

  • Non-animal testing
  • Food safety
  • Legislation
  • TOXICOLOGICAL CONCERN TTC
  • INTEGRATED TESTING STRATEGIES
  • PHYTOSTEROL-ESTERS
  • ENVIRONMENTAL CHEMICALS
  • CONTROLLED DIET
  • THRESHOLD
  • MODEL
  • GENERATION
  • PREDICTION
  • GUIDANCE

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