TY - JOUR
T1 - Angiotensin type 2 receptors: blood pressure regulation and end organ damage
AU - Sumners, Colin
AU - de Kloet, Annette D.
AU - Krause, Eric G.
AU - Unger, Thomas
AU - Steckelings, Ulrike Muscha
PY - 2015/4
Y1 - 2015/4
N2 - In most situations, the angiotensin AT2-receptor (AT2R) mediates physiological actions opposing those mediated by the AT1-receptor (AT1R), including a vasorelaxant effect. Nevertheless, experimental evidence vastly supports that systemic application of AT2R-agonists is blood pressure neutral. However, stimulation of AT2R locally within the brain or the kidney apparently elicits a systemic blood pressure lowering effect. A systemic effect of AT2R stimulation on blood pressure can also be achieved, when the prevailing effect of continuous background AT1R-stimulation is attenuated by low-dose AT1R blockade. Despite a lack of effect on blood pressure, AT2R stimulation still protects from hypertensive end-organ damage. Current data and evidence therefore suggest that AT2R agonists will not be suitable as future antihypertensive drugs, but that they may well be useful for end-organ protection in combination with established anti-hypertensives.
AB - In most situations, the angiotensin AT2-receptor (AT2R) mediates physiological actions opposing those mediated by the AT1-receptor (AT1R), including a vasorelaxant effect. Nevertheless, experimental evidence vastly supports that systemic application of AT2R-agonists is blood pressure neutral. However, stimulation of AT2R locally within the brain or the kidney apparently elicits a systemic blood pressure lowering effect. A systemic effect of AT2R stimulation on blood pressure can also be achieved, when the prevailing effect of continuous background AT1R-stimulation is attenuated by low-dose AT1R blockade. Despite a lack of effect on blood pressure, AT2R stimulation still protects from hypertensive end-organ damage. Current data and evidence therefore suggest that AT2R agonists will not be suitable as future antihypertensive drugs, but that they may well be useful for end-organ protection in combination with established anti-hypertensives.
U2 - 10.1016/j.coph.2015.01.004
DO - 10.1016/j.coph.2015.01.004
M3 - Article
SN - 1471-4892
VL - 21
SP - 115
EP - 121
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
ER -