Angiotensin type 2 receptors: blood pressure regulation and end organ damage

Colin Sumners, Annette D. de Kloet, Eric G. Krause, Thomas Unger, Ulrike Muscha Steckelings*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


In most situations, the angiotensin AT2-receptor (AT2R) mediates physiological actions opposing those mediated by the AT1-receptor (AT1R), including a vasorelaxant effect. Nevertheless, experimental evidence vastly supports that systemic application of AT2R-agonists is blood pressure neutral. However, stimulation of AT2R locally within the brain or the kidney apparently elicits a systemic blood pressure lowering effect. A systemic effect of AT2R stimulation on blood pressure can also be achieved, when the prevailing effect of continuous background AT1R-stimulation is attenuated by low-dose AT1R blockade. Despite a lack of effect on blood pressure, AT2R stimulation still protects from hypertensive end-organ damage. Current data and evidence therefore suggest that AT2R agonists will not be suitable as future antihypertensive drugs, but that they may well be useful for end-organ protection in combination with established anti-hypertensives.
Original languageEnglish
Pages (from-to)115-121
JournalCurrent Opinion in Pharmacology
Publication statusPublished - Apr 2015


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