Angiotensin type 2 receptors: blood pressure regulation and end organ damage

Colin Sumners; Annette D. de Kloet; Eric G. Krause; Thomas Unger; Ulrike Muscha Steckelings

doi:10.1016/j.coph.2015.01.004

Angiotensin type 2 receptors: blood pressure regulation and end organ damage

Colin Sumners, Annette D. de Kloet, Eric G. Krause, Thomas Unger, Ulrike Muscha Steckelings^*

^*Corresponding author for this work

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Abstract

In most situations, the angiotensin AT2-receptor (AT2R) mediates physiological actions opposing those mediated by the AT1-receptor (AT1R), including a vasorelaxant effect. Nevertheless, experimental evidence vastly supports that systemic application of AT2R-agonists is blood pressure neutral. However, stimulation of AT2R locally within the brain or the kidney apparently elicits a systemic blood pressure lowering effect. A systemic effect of AT2R stimulation on blood pressure can also be achieved, when the prevailing effect of continuous background AT1R-stimulation is attenuated by low-dose AT1R blockade. Despite a lack of effect on blood pressure, AT2R stimulation still protects from hypertensive end-organ damage. Current data and evidence therefore suggest that AT2R agonists will not be suitable as future antihypertensive drugs, but that they may well be useful for end-organ protection in combination with established anti-hypertensives.

Original language	English
Pages (from-to)	115-121
Journal	Current Opinion in Pharmacology
Volume	21
DOIs	https://doi.org/10.1016/j.coph.2015.01.004
Publication status	Published - Apr 2015

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10.1016/j.coph.2015.01.004

Cite this

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title = "Angiotensin type 2 receptors: blood pressure regulation and end organ damage",

abstract = "In most situations, the angiotensin AT2-receptor (AT2R) mediates physiological actions opposing those mediated by the AT1-receptor (AT1R), including a vasorelaxant effect. Nevertheless, experimental evidence vastly supports that systemic application of AT2R-agonists is blood pressure neutral. However, stimulation of AT2R locally within the brain or the kidney apparently elicits a systemic blood pressure lowering effect. A systemic effect of AT2R stimulation on blood pressure can also be achieved, when the prevailing effect of continuous background AT1R-stimulation is attenuated by low-dose AT1R blockade. Despite a lack of effect on blood pressure, AT2R stimulation still protects from hypertensive end-organ damage. Current data and evidence therefore suggest that AT2R agonists will not be suitable as future antihypertensive drugs, but that they may well be useful for end-organ protection in combination with established anti-hypertensives.",

author = "Colin Sumners and {de Kloet}, {Annette D.} and Krause, {Eric G.} and Thomas Unger and Steckelings, {Ulrike Muscha}",

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T1 - Angiotensin type 2 receptors: blood pressure regulation and end organ damage

AU - Sumners, Colin

AU - de Kloet, Annette D.

AU - Krause, Eric G.

AU - Unger, Thomas

AU - Steckelings, Ulrike Muscha

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N2 - In most situations, the angiotensin AT2-receptor (AT2R) mediates physiological actions opposing those mediated by the AT1-receptor (AT1R), including a vasorelaxant effect. Nevertheless, experimental evidence vastly supports that systemic application of AT2R-agonists is blood pressure neutral. However, stimulation of AT2R locally within the brain or the kidney apparently elicits a systemic blood pressure lowering effect. A systemic effect of AT2R stimulation on blood pressure can also be achieved, when the prevailing effect of continuous background AT1R-stimulation is attenuated by low-dose AT1R blockade. Despite a lack of effect on blood pressure, AT2R stimulation still protects from hypertensive end-organ damage. Current data and evidence therefore suggest that AT2R agonists will not be suitable as future antihypertensive drugs, but that they may well be useful for end-organ protection in combination with established anti-hypertensives.

AB - In most situations, the angiotensin AT2-receptor (AT2R) mediates physiological actions opposing those mediated by the AT1-receptor (AT1R), including a vasorelaxant effect. Nevertheless, experimental evidence vastly supports that systemic application of AT2R-agonists is blood pressure neutral. However, stimulation of AT2R locally within the brain or the kidney apparently elicits a systemic blood pressure lowering effect. A systemic effect of AT2R stimulation on blood pressure can also be achieved, when the prevailing effect of continuous background AT1R-stimulation is attenuated by low-dose AT1R blockade. Despite a lack of effect on blood pressure, AT2R stimulation still protects from hypertensive end-organ damage. Current data and evidence therefore suggest that AT2R agonists will not be suitable as future antihypertensive drugs, but that they may well be useful for end-organ protection in combination with established anti-hypertensives.

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DO - 10.1016/j.coph.2015.01.004

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